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Study on the Effect of Geopungjeseup-tang in Rheumatoid Arthritis  

Hong, Sun-Sung (Department of Oriental Medicine, Oriental Rehabilitation Medicine Daejeon University)
Yoon, Il-Ji (Department of Oriental Medicine, Oriental Rehabilitation Medicine Daejeon University)
Oh, Min-Suck (Department of Oriental Medicine, Oriental Rehabilitation Medicine Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.5, 2006 , pp. 1241-1244 More about this Journal
Abstract
This study was carried out to know the effect of Geopungjeseup-tang(GPJST) to on Rheumatoid Arthritis by using human fibroblast-like synoviocytes(hFLS). GPJST consists of Coisis Semen, Coccllus Trilobus DC., Lycopi Herba, Arisaematis Rhizoma. The author peformed several experimetal items : that is cytotoxicity of GPJST, mRNA expression of TNF-${\alpha}$, IL-1${\beta}$, ICAM-1, production of NO. The results were obtained as follows : The mRNA expression of pro-inflammatory cytokines TNF-${\alpha}$, IL-1${\beta}$, ICAM-1 were dose-dependently reduced in hFLS. The production of NO was reduced. Talking all these observations into account, GPJST is considered to be effective in treating rheumatoid arthritis. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.
Keywords
Geopungjeseup-tang(GPJST); Rheumatoid arthritis;
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1 김성윤. 류마티스 관절염의 진단과 치료, 가정의학학회지, 18(11):1279-1290, 1997
2 곽중문. 疎風活血湯加味가 류마토이드 關節炎 患者에서 分離한 synoviocytes에 대한 免疫反應과 collagen으로 誘發된 생쥐의 關節炎 抑制에 관한 硏究, 대전대학교대학원, 2002
3 Dustin, M.L., Singer, K.H., Tuck, D.T., Springer, T.A. Expression of the lymphoblasts to epidermal keratinocytes is regulated by INF-$\gamma$ and is mediated by ICAM-1, J Exp Med, 167:1323, 1988   DOI   ScienceOn
4 Shapel, S.B., Toman, C., Anderson, D.C. MAC-1(CD11b/ CD18) mediates adherence dependant hydrogen peroxidase production by human and canine neutrophils, J immunol, 144:2702, 1990
5 Schlaak, J.F., Pfers, I., Meyer, Zum, Buschenfelde, K.H., Marker-Hermann, E. Differant cytokine profiles in the synovial fluid of patient with osteoarthritis, rheumatoid arthritis and seronegative spondyloarthropathies, Clin Exp Rheumarol, 14:63-88, 2002
6 金荀中. Adjuvant관절염에 疎經活血湯合黃連解毒湯이 미치는 實驗的 硏究, 대전대학교대학원, 1992
7 해리슨 번역 편찬위원회. 해리슨 내과학, 서울, 도서출판정담, pp 179, 1783, 1779-1785, 1997
8 Waddington, R.J., Moseley, R., Embery, G. Reactive oxygen species : a potential role in the pathogenesis of periodontal disease, Oral Dis, 6:138-151, 2000   DOI   ScienceOn
9 諸正鎭. 血府逐瘀湯이 Adjuvant誘發 關節炎에 미치는 影響, 경희대학교대학원, 1993
10 대한정형외과학회. 정형외과학, 서울, 최신의학사, p 175, 1999
11 Ribbens, C., Andre, B., Kaye, O., Kaiser, M.J., Bonnet, V., de Groote, D., Franchimont, N., Malaise, M.G. Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies, Eur Cytokine Newt, 11:669-676, 2000
12 申敏湜. 防風湯이 Adjuvant誘發 關節炎에 미치는 影響, 경희대학교대학원, 1994
13 정수현. 三痺湯이 Collagen으로 유발된 관절염에 미치는 영향, 한방재활의학과학회지, 10(1):173-183, 2000
14 申炳熙. 桂枝芍藥知母湯이 第 II 型 Collagen誘發 關節炎의 抗體에 미치는 影響, 경희대학교대학원, 1994
15 김영태, 이재동, 이윤호. 최근 RA와 관련된 임상 및 실험 논문의 경향, 대한침구학회지, 19(5):190-194, 2002
16 李世鉉. 行濕流氣散이 Adjuvant關節炎에 미치는 影響, 대전대학교대학원, 1992
17 Halliwell, B. Oral inflammation and reactive species : a missed opportunity, Oral Dis, 6:136-137, 2000   DOI   ScienceOn
18 李昊根. 大羌活湯이 제II형 Collagen誘發 關節炎의 抗體에 미치는 影響, 경희대학교대학원, 1994
19 이중휘. Type II Collagen으로 誘發된 關節炎에 대한 疏經活血湯加味의 免疫 抑制 效果, 대전대학교대학원, 2004
20 전국한의과대학재활의학과학교실. 동의재활의학과학, 서울, 서원당, pp 111-116, 1995