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Cytotoxicity of Angelicae Radix from Korea, China, and Japan on HepG2 Cells  

Park, Wan-Su (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Oh, Myung-Sook (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Chang, Mun-Seog (Department of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School)
Yang, Woong-Mo (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Lee, Byong-Hee (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Kim, Won-Nam (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Lee, Hak-Chul (Department of Oriental Preventive Medicine, College of Oriental Medicine, Dong-Eui University)
Kang, Soon-Ah (Department of Fermented Food Science, Seoul University of Venture & Information)
Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.5, 2006 , pp. 1155-1158 More about this Journal
Abstract
The purpose of this study is to examine the cytotoxicity of species of Angelica (Angelicas Radix; the root of Angelica gigas Nakai, A. sinensis (Oliv.) Diels, and A. acutiloba Kitag.) on HepG2 cells. The water extracts of roots of Angelica gigas (WAG), A. sinensis (WAS), and A. acutiloba (WAA) were studied for HepG2 cell viability by a modified MTT assay in the concentrations of 5, 10, 50, 100, 250, 500 ug/ml for 24, 48, 72 h. WAG and WAS did not reduced the cell viability significantly. But WAA reduced the cell viability in the concentration of 500 ug/ml for 24 h (85.45%), 48 h (75.01%). In conclusion, WAG and WAS have not the significant cytotoxicity on HepG2 cells in the suitable dose.
Keywords
Angelicae Radix; HepG2 cells; cytotoxicity; MTT assay;
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Times Cited By KSCI : 1  (Citation Analysis)
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