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Anti-Inflammatory Effect of Haepyoejin-tang plus Antler water extract in Xylene-Application Mouse Ear Acute Inflammation Model  

Jung, Bong-Gyun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Jeon, Kwi-Ok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Park, Mee-Yeon (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Choi, Hae-Yun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Kim, Jong-Dae (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Cho, Dong-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.4, 2006 , pp. 985-991 More about this Journal
Abstract
In the present study, the anti-inflammatory effect of Haepyoeiin-tang plus Antler water extract water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on Dody weight and weights and histopathological observation of induced ear were conducted with ear histomorphometry, The increases of absolute and relative ear weight detected in vehicle control compared to that of sham, were significantly and dose-dependently inhibited by Haepyoejin-tang plus Antler in the present study, A classic acute inflammatory histological changes such as subcutaneous edema, hypertrophy and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Haepyoeiin-tang plus Antler. In addition, the increases of ear thickness half and thickness full detected in the vehicle control, were also dose-dependently decreased in the all Haepyoeiin-tang plus Antler-dosing groups. Base on these results, it is concluded that Haepyoeiin-tang plus Antler water extracts have a clear anti-inflammatory effect on the acute inflammation. However, somewhat lower anti-inflammatory effects were detected in Haepyoeiin-tang plus Antler water extracts compare to that of Dethamethason and Dicrofenac. About 500 mg/kg of Haepyoeiin-tang plus Antler water extracts have similar effect compared to that of Dicrofenac 15 mg/kg.
Keywords
Anti-Inflammatory Effect; Haepyoejin-tang plus Antler; Xylene-Application mouse;
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1 전국한의과대학 본초학교수 편저. 본초학. 서울, 영림사, p 123, 126, 460, 464, 478, 481, 484, 541, 1995
2 이경태, 박동일. 해표이진탕이 흰쥐의 $SO_2$에 의한 호흡기손상에 미치는 영향. 한의학회지 17(2):178-190, 1996
3 Hosseinzadeh, H., Haddadkhodaparast, M.H., Arash, A.R. Antino-ciceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth seed extract in mice and rats. Phytother Res, 17(4):422-425, 2003   DOI   ScienceOn
4 Abdel-Salam, O.M., Baiuomy, A.R., El-batran, S., Arbid, M.S. Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat, Pharmacol Res, 49(2):133-142, 2004   DOI   ScienceOn
5 Vetrichelvan, T., Jegadeesan, M. Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. Phytother Res, 17(1):77-79, 2003   DOI   ScienceOn
6 Gomez, M.A., Saenz, M.T., Garcia, M.D., Fernandez, M.A. Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models. Z Naturforsch [C], 54(11):937-941, 1999
7 Rossetti, R.G., Seiler, C.M., Brathwaite, K., Zurier, R.B. Effect of Misoprostol on Acute and Chronic Inflammation. Am J Ther, 2(9):600-606, 1995   DOI   ScienceOn
8 Zhong, Z., Zhou, G., Chen, X., Huang, P. Pharmacological study on the extracts from Typhonium flagelliforme Blume. Zhong Yao Cai, 24(10):735-738, 2001
9 Hosseinzadeh, H., Ramezani, M., Salmani, G. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol, 73(3):379-385, 2000   DOI   ScienceOn
10 Rotelli, A.E., Guardia, T., Juarez, A.O., de la Rocha, N.E., Pelzer, L.E. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res, 48(6):601-606, 2003   DOI   ScienceOn
11 De La Puerta, R., Martinez, E., Bravo, L., Ahumada, M.C. Effect of silymarin on different acute inflammation models and on leukocyte migration. J Pharm Pharmacol, 48(9):968-970, 1996   DOI   ScienceOn
12 Barns, P., Pederson, S. Efficacy and safety of inhaled cortico- steroids in asthma, Am Rev Respir Dis, 148, 1-26, 1993   DOI
13 신재용. 방약합편해설. 서울, 성보사, p 133, 1998
14 Leclerc, N., Noh, T., Khokhar, A., Smith, E., Frenkel, B. Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Arthritis Rheum, 52(3):929-939, 2005   DOI   ScienceOn
15 Giner-Larza, E.M., Manez, S., Giner, R.M., Recio, M.C., Prieto, J.M., Cerda-Nicolas, M., Rios, J.L. Anti-inflammatory triterpenes from Pistacia terebinthus galls. Planta Med, 68(4):311-315, 2002   DOI   ScienceOn
16 백동진, 정희재, 이형구, 정승기. 해표이진탕가감방이 천식 모델 내의 Cytokine에 미치는 영향. 한의학회지 21(3):57-66, 2000
17 Atta, A.H., Alkofahi, A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol, 60(2):117-124, 1998   DOI   ScienceOn
18 Hosseinzadeh, H., Younesi, H.M. Antinociceptive and anti-inflammatory effects of Crocus sativus L, stigma and petal extracts in mice. BMC Pharmacol, 2(1):7, 2002   DOI
19 Kou, J., Ma, R., Zhu, D., Yan, Y. Blood-activating and anti-inflammatory actions of Polygala fallax. Zhong Yao Cai, 26(4):268-271, 2003
20 Al-Majed, A.A., Khattab, M., Raza, M., Al-Shabanah, O.A., Mostafa, A.M. Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan- induced acute inflammation in rats: the role of nitric oxide. Inflamm Res, 52(9):378-382, 2003   DOI   ScienceOn
21 한용철. 임상호흡기학. 서울, 일조각, p 208, 219, 1993
22 Kou, J., Ni, Y., Li, N., Wang, J., Liu, L., Jiang, Z.H. Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal ants Polyrhachis lamellidens Biol Pharm Bull, 28(1):176-180, 2005   DOI   ScienceOn
23 朴東一, 李珩九. 解表二陳湯이 鎭痛, 鎭痙, 解熱 및 O3 中毒으로 인한 흰쥐 肺損傷에 미치는 影響. 慶熙韓醫大論文集, 9, 463-470, 1986
24 Waddell, A.N., Patel, S.K., Toma, A.G., Maw, A.R. Intranasal steroid sprays in the treatment of rhinitis: is one better than another? J Laryngol Otol, 117(11):843-845, 2003
25 Hosseinzadeh, H., Ramezani, M., Fadishei, M., Mahmoudi, M. Anti-nociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. Phytomedicine, 9(2):135-141, 2002   DOI   ScienceOn
26 대한병리학회 편. 병리학. 서울, 고문사, pp 65-68, 83, 1998
27 Roh, G.S., Seo, S.W., Yeo, S., Lee, J.M., Choi, J.W., Kim, E., Shin, Y., Cho, C., Bae, H., Jung, S.K., Kwack, K. Efficacy of a traditional Korean medicine, Chung-Sang-Bo-Ha-Tang, in a murine model of chronic asthma. Int Immunopharmacol, 5(2):427-436, 2005   DOI   ScienceOn
28 허준. 東醫寶鑑. 서울, 남산당, p 134, 481, 1987
29 Ojewole, J.A. Antinociceptive, anti-inflammatory and anti-diabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract. J Ethnopharmacol, 99(1):13-19, 2005   DOI   ScienceOn
30 賣得道. 中國醫學史略. 山西, 山西人民出版社, p 243, 1979