Browse > Article

Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients  

Lee, Seoung-Geun (Department of International Medicine of Oriental Medicine Hospital, Wonkwang University)
Lee, Key-Sang (Department of International Medicine of Oriental Medicine Hospital, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.4, 2006 , pp. 929-935 More about this Journal
Abstract
This study was to investigate the effect of Danchunwhangagam(DCWGG) extract on the production of proinflammatory cytokines in peripheral mononuclear cells (PBMCS) from Cerebral infarction(CI) patients. Methods: We examined that the inhibition rate of tumor necrosis factor $(TNF)-{\alpha},\;interleukin(IL)-1{\alpha},\;IL-1{\beta}$, IL-6, and IL-8 productions in DCWGG pretreatment PBMCs culture supernatant in the lipopolysaccaride(LPS)- or Oesferrioxamine(DFX)-treated cells compared to unstimulated cells. DCWGG inhibited the productions of $TNF-{\alpha},\;IL-1{\alpha},\;IL-1{\beta}$, IL-6, and IL-8 induced by LPS in a dose-dependent manner DCWGG might have regulatory effects on LPS or DFX-induced cytokine production, which might explain its beneficial effect in the treatment of CI.
Keywords
Danchunwhangagam; Cerebral Infarction; Cytokine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Jeong, H.J., Chung, H.S., Lee, B.R., Kim, S.J., Yoo, S.J., Hong, S.H., Kim, H.M. Expression of proinflammatory cytokines via HIF-1alpha and NF-kappaB activation on desferrioxamine-stimulated HMC-1 cells. Biochem Biophys Res Commun. Jul 11, 306(4):805-811, 2003   DOI   ScienceOn
2 Shin, M.K. Clinical traditional herbalogy. Seoul: Younglim, pp 519-521, 518-519, 699-701, 1997
3 Chertov, O., Michiel, D.F., Xu, L., Wang, J.M., Tani, K., Murphy, W.J., Longo, D.L., Taub, D.D., Oppenheim, J.J. Indentification of defensin-1, defensin-2, and CAP37/Azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. Journal of Biological Chemistry. 271:2935-2940, 1996   DOI
4 Na, Y.H. Effects of Dancheonhwan on Hydrogen Peroxide-induced Apoptosis of H9c2 Cardiomyoblasts. Wonkwang Univ. 1, 2001
5 Ross, R. Atherosclerosis: an inflammatory disease. New England Journal of Medicine. 340:115-126, 1999   DOI   ScienceOn
6 Woods, A., Brull, D.J., Humphries, S.E., Montgomery, H.E. Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6. European Heart Journal. 21:1574-1583, 2000   DOI   ScienceOn
7 Shohami, E., Ginis, I., Allenbeck, J.M. Dual role of tumor necrosis factor alpha in brain injury. Cytokine & Growth Factor Reviews. 10:119-130, 1999   DOI   ScienceOn
8 Touzani, O., Boutin, H., Chuquet, J., Rothwell, N. Potential mechanisms of interleukin-1 involvement in cerebral ischaemia. J Neuroimmunol. 100:203-215, 1999   DOI
9 Hillhouse, EW, Kida, S., Iannotti, F. Middle cerebral artery occlusion in the rat causes a biphasic production of immunoreactive interleukin-1beta in the cerebral cortex. Neurosci Lett. 249:177-179, 1998   DOI
10 Choi, Y.S. Effects of allolobophora caliginosatrapezoides extracts and polysaccharide franction on the inflammation and immune reaction. Chungang Univ. 1989
11 Vila, N., Reverter, J.C., Yague, J., Chamorro, A. Interaction between interleukin-6 and the natural anticoagulant system in acute stroke. Journal of Interferon and Cytokine Research. 20:325-329, 2000   DOI   ScienceOn
12 Weiss, G., Fuchs, D., Hausen, A., Reibnegger, G., Werner, E.R., Werner-Felmayer, G., Wachter, H. Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1. Exp Hematol. Jun, 20(5):605-610, 1992
13 Hallenbeck, J.M. The many faces of tumor necrosis factor in stroke. Nature Medicine. 8:1363-1368, 2002   DOI   ScienceOn
14 Jo, N.S. Spatholobus suberectus Water Extract induces Apoptotic Cell Death via Inhibition of Cell Cycle in Jurkat Human Leukemia Cell Line. Wonkwang Univ. 2002
15 Stoll, G., Jander, S., Schroeter, M. Inflammation and glial responses in ischemic brain lesions. Progress in Neurobiology. 56:149-171, 1998   DOI   ScienceOn
16 Wang, X., Yue, T.L., Barone, F.C., White, R.F., Gagnon, R.C., Feuerstein, G.Z. Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia. Mol Chem Neuropathol. 23:103-114, 1994   DOI   ScienceOn
17 Tomimoto, H., Akiguchi, I., Wakita, H., Kinoshita, A., Ikemoto, A., Nakamura, S., Kimura, J. Glial expression of cytokines in the brains of cerebrovascular disease patients. Acta Neuropathologica. 92:281-287, 1996   DOI   ScienceOn
18 Taub, D.D., Anver, M., Oppenheim, J.J., Longo, D.L., Murphy, W.J. T lymphocyte recruitment by interleukin-8 (IL-8). Journal of Clinical Investigation. 97:1931-1941, 1996   DOI
19 Rothwell, N.J., Luheshi, G.N. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 23:618-625, 2000   DOI   ScienceOn
20 Han, S.H. Effects of Danchunhwan Water Extract on Oxidative Damage of Human Neural Cell. Wonkwang Univ. 2000
21 Kim, I.T., Park, Y.M., Shin, K.M., Ha, J., Choi, J., Jung, H.J., Park, H.J., Lee, K.T. Anti-inflammatory and anti-nociceptive effects of the extract from Kalopanax pictus,Pueraria thunbergiana and Rhus verniciflua. J Ethnopharmacol. 94:165-173, 2004   DOI   ScienceOn
22 Fassbender, K., Rossol, S., Kammer, T.,Daffertshofer, M., Wirth, S., Dollman, M. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. Journal of Neuroscience. 19:135-139, 1994
23 Matsumoto, T., Ikeda, K., Mukaida, N., Harada, A., Matsumoto, Y., Yamashita, J., Matsushima, K. Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8. Laboratory Investigation. 77:119-125, 1997
24 Ferrarese, C., Mascarucci, P., Zoia, C., Cavarretta, R., Frigo, M., Begni, B. Increased cytokine release from peripheral blood cells after acute stroke. Journal of Cerebral Blood Flow and Metabolism. 6:1004-1009, 1999
25 Kawamata, T., Dietrich, W.D., Schallert, T., Gotts, J.E., Cocke, R.R., Benowitz, L.I., Finklestein, S.P. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proceedings of The National Academy of Sciences of the United States of America. 94:8179-8184, 1997
26 Benveniste, E.N. Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action. American Journal of Physiology-Cell Physiology. 263:116-122, 1992   DOI
27 Zhang, Z., Chopp, M., Goussev, A., Powers, C. Cerebral vessels express interleukin 1beta after focal cerebral ischemia. Brain Res. 784:210-217, 1998   DOI
28 Choi, B.H. Effect of Cnidii Rhizoma Water Extract on the Cerebral Blood Flow. Wonkwang Univ. 2003
29 Ryu, J.H. Effect in Salviae Radix Extract on Blood Pressure in Hypertensive Rat. Wonkwang Univ. 2001