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Inhibitory Effect of Extract of Ficis Folium on the Sebum Synthesis in Human Sebocyte Cell Line (SZ95)  

Park, Si-Jun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Yeong-Mok (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Lim, Kyu-Sang (Department of Ophthalmology Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University)
Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.4, 2006 , pp. 919-923 More about this Journal
Abstract
Sebum is an oily substance produced by sebaceous glands in human skin. The differentiation of the sebaceous gland is remarkably species-specific and sebocytes may play crucial parts in the pathophysiologic processes and disorders of pilosebaceous unit. In this study, we investigated the inhibitory effect of Ficis folium on the lipid production using the human sebocyte cell line 5195. Our results showed that Ficis folium significantly inhibits synthesis of sebaceous lipids such as cholesterol esters, triglycerides, and total lipid. And Ficis folium supressed cytoplasmic lipid droplets. On the other hand, Ficis folium didn't effect on cell proliferation. These results suggest treatment with Ficis folium resulted in a lower lipid synthesis in SZ95 cells without cytotoxicity.
Keywords
sebaceous lipids; Ficis folium; cholesterol; triglycerides;
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Times Cited By KSCI : 1  (Citation Analysis)
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