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Effects of the Geijibokryunghwan on Carrageenan-induced Inflammation and COX-2 in Hepatoma Cells  

Joo, Shin-Tak (Department of Diagnostics and Cardiovascular Medical Research Center, Dongguk University)
Ban, Chang-Gyu (Department of Diagnostics and Cardiovascular Medical Research Center, Dongguk University)
Park, Soon-Gi (Department of Diagnostics and Cardiovascular Medical Research Center, Dongguk University)
Park, Won-Hwan (Department of Diagnostics and Cardiovascular Medical Research Center, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.4, 2006 , pp. 1027-1031 More about this Journal
Abstract
In oriental medicine, Geijibokryunghwan(GBH) was used to improvement various symptoms created by the thrombosis. We investigated the effects of an oriental medicinal prescriptions, Geijibokryunghwan (GBH) consisting of herbs of Cinnamomi Ramufus (Geiji; 桂枝), Poria cocos (Bokrung; 茯?), Moutan Cortex Radicis(Modanpi; 牧丹皮), Paeoniae Radix (Jakyak; 芍藥) and Persicae Semen (Doin; 桃仁) on tumor growth-inhibitory activity and cancer chempreventive activity in assays representing three maior stages of carcinogenesis. Cancer chempreventive agents include nonsteroidal anti-inflammatory drugs (NSAIDS) such as indomethacin, aspirin, piroxicam, and sulindac, all of which inhibit cyclooxygenase (COX). Effects of the GBH extracts on carrageenan-induced edema Inflammation using female (C57BL/6XC3H) Fl (B6C3Fl ) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chempreventive agent in humans.
Keywords
Chemoprevention; inflammation; COX-2; Geijibokryunghwan(GBH); thrombosis;
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