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Effect of Water Extract of KH-304 on Anti-oxidant and Erectile dysfunction in Old Rat  

Lee, Eun-Jeong (Korea Medical Science Institute)
Lee, Hyun-Ji (Korea Medical Science Institute)
Kim, Hee-Seok (Korea Medical Science Institute)
Hwang, Sung-Wan (Korea Medical Science Institute)
Hwang, Sung-Yeoun (Korea Medical Science Institute)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.4, 2006 , pp. 1009-1013 More about this Journal
Abstract
The fallowing are the result of the experimental studies of KH-304 on the penile nitric oxide synthase (NOS) activity, SOD and the level of blood testosterone in old rat. KH-304 was tested for the expression and activity of eNOS, nNOS, SOD/Mn, caveol in-1, 3 in penis of old-rat. The penile expression level of the five enzyme were increased significantly after oral administration of the KH-304 100mg/kg for 100ays and the concentration of testosterone in the blood were increased. In vitro, the effect of SOD and free radical scavenging were increased significantly. Conclusively, KH-304 is capable of improving of sexual ability in old-rat.
Keywords
NOS; SOD; Old-rat; testosterone; erectile dysfunction;
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1 차배천, 이성규, 이혜원, 이은, 최무영, 임태은, 박희준. 국내 유용식물의 항산화효과. 생약학회지 28(1):15-20, 1997
2 김제종. 남성노화에 따른 성기능의 변화. 18(1):1-5, 2000
3 Kurt, J. 내과학. 서울, 정담, pp 287-288, 1997
4 Davidson, J.M, Chen, J.J. Crapo, L, Gray, G.D., Greenleaf, W.J, Hormonal changes and sexual function in aging male, J Clin Endocrinol Metabol, 57(2):557-562, 1983   DOI
5 Bancroft, J.W., Wu, F.C. Changes in erectile responsiveness during androgen therapy. Arch Sex Behav, 12(2):59-66, 1983   DOI   ScienceOn
6 Bruce N.A., Mark K.S., Tory M.H. Oxidants, anti oxidants and the degenerative diseases of aging. Proc. Natl.Acad.Sci 90(4):7915-7922, 1993   DOI   ScienceOn
7 Kitahara, K., Matsumoto, Y., Ueda, H., Ueoka, R. A remarkable antioxidation effect of natural phenol derivatives on the autoxidation of r-irradiated methyl linolete. Chem. Pharm. Bull, 40, 2208-2209, 1992   DOI
8 Masaki, H., Sakaki, S., Atsumi. T. Active-oxygen scavenging activity of plant extracts. Chem. Pharm. Bull, 18(1):162- 166, 1995   DOI   ScienceOn
9 이종욱. 비뇨기과학. 서울, 고려의학, pp 462-463, 1996
10 Schmidt, H.W., Smith, R.M., Nakzne, M., Murad, F. Ca2+/ calmodulin dependent NO synthase Type-1 : A biopteroflavo- protein with $Ca^{2+}$/ calmodulin in dependent diaphorase and reductase activities. Biochem., 32(4):3243-3249, 1992
11 Chung, H.C. Role of nitric oxide in penile erection, Ph .D. Thesis. Yeungnam Univ. 1995
12 Carani, C.M., Scutery, A., Marrama, P., Bancroft, J. The effects of testosterone administration and visual erotic stimuli on nocturnal penile tumiscince in normal young men. Horm Behav 24(2):435-441, 1990   DOI
13 Halliwell, B. Drug antioxidant effects. Drugs. 42, 569-605, 1991   DOI   ScienceOn
14 Fukuzawa, K., Takaishi, Y. Antioxidants, J. Act. Oxyg. Free Rad, 1, 55-70, 1990