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Screening of the Positive Inotropic Activity of Medicinal Plants Used in Oriental Medicine  

Choi, Deok-Ho (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang, Dae-Gil (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Seung-Ju (Professional Graduate School of Oriental Medicine, Wonkwang University)
Cui, Xun (Department of Physiology, Yanbian University College of Medicine)
Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.3, 2006 , pp. 730-734 More about this Journal
Abstract
Aqueous extracts of medicinal plants traditionally used in the East Asia such as China, Korea, and Japan were screened for inotropic activity using isolated rabbit atria. Among the twenty-one aqueous-extracts from medicinal plants, the aqueous extracts of Convallaria keiskei(ACK) and rhizome of Coptis chinesis (ACC) were found to exhibit distinctive positive inotropic activity. The aqueous extracts of C. keiskei and rhizome of C. chinensis significantly increased atrial stroke volume and pulse pressure in beating rabbit atria. These findings suggest that the aqueous extracts of C. keiskei and rhizome of C. chinensis enhance the cardiac muscle contractility and then could be useful for the treatment of cardiac failure.
Keywords
inotropic activity; atrial stroke volume; pulse pressure; cardiac failure; Oriental medicines;
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1 Felker, G.M., O'Connor, C.M. Inotropic therapy for heart failure: an evidence-based approach. American Heart Journal 142, 393-401, 2001   DOI
2 Konstam, M.A., Mann, D.L. Contemporary medical options for treating patients with heart failure. Circulation 105, 2244-2246, 2002   DOI   ScienceOn
3 Simaan, J.A., Faswaz, G., Jabbour, K. Comparison of the cardiodynamic and metabolic effects of dobutamine with those of norepinephrine and dopamine in the isolated heart. Naunyn-Schmiedeberg's Arch Pharmacal 338, 174-179, 1988
4 Schmeller, T., Latz-Bruning, B., Wink, M. Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores. Phytochemistry 44, 257-266, 1997   DOI   ScienceOn
5 Zeng, X., Zeng, X. Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC. Biomedical Chromatography 13(7):442-444, 1999   DOI   ScienceOn
6 Ko, W.H., Yao, X.O., Lau, C.W., Law, W.I., Chen, Z.Y., Kwok, W., Ho, K., Huang, Y. Vasorelaxant and antiproliferative effect of berberine. European Journal of Pharmacology 399, 187-196, 2000   DOI
7 Kimura, M., Thoma, M., Yoshizawa, I. The constituents of Convallaria. VII. Structure of convallagenin-A. Chemical & Pharmaceutical Bulletin 15(8):1204-1211, 1967   DOI   ScienceOn
8 Wolfgang, K., Brigitte, K., Kurt, J., Helmut, R. Zur biogenese von strophanthidin-glycosiden: Convallatoxol als vorstufe von convallatoxin in Convallaria majalis. Phytochemistry 13, 1805-1808, 1974   DOI   ScienceOn
9 Ozaki, H., Nagase, H., Urakawa, N. Interaction of palytoxin and cardiac glycosides on erythrocyte membranes and $Na^+-K^+$ ATPase. European Journal of Biochemistry 152, 475-480, 1985   DOI   ScienceOn
10 Cho, K.W., Kim, S.H., Kim, C.H., Seul, K.H. Mechanical basis of ANP secretion in beating atria: atrial stroke volume and ECF translocation. American Journal of Physiology 268, 1129-1136, 1995
11 Tang, W., Eisenbrand, G. Chinese crugs of plant origine: chemistry, pharmacology, and used in traditional and modern medicine. Springer-Verlag, Berlin, Germany, pp 361-371, 1992
12 Kimura, M., Thoma, M., Yoshizawa, I. The constituents of Convallaria. II. The isolation of convallasaponin-A, -B, -C. Chemical & Pharmaceutical Bulletin 14(1):50-55, 1966   DOI   ScienceOn
13 Katz, A. Potential deleterious effect of inotropic agents in the therapy of chronic heart failure. Circulation 73, 184-190, 1986
14 Alpert, N.R., Mulieri, L.A., Warshaw, D. The failing human heart. Cardiovascular Research. 54, 1-10, 2002   DOI   ScienceOn
15 Guyton, A.C., Hall, J.E. Textbook of medical physiology. 9th Ed., Saunders, Pennsylvania, 107-119, 1996
16 Lau, C.W., Yao, X.Q., Chen, Z.Y., Ko, W.H., Huang, Y. Cardiovascular action of berberine. Cardiovascular Drug Review 19, 234-244, 2001
17 Francis, G.S. Pathophysiology of chronic heart failure. American Journal of Medicine. 110, 37-46, 2001   DOI
18 Kimura, M., Thoma, M., Kikuchi, T. The constituents of Convallaria. II. The isolation of desglucocheirotoxin. Japanese Journal of Pharmacology 82, 1320-1323, 1962
19 Katzung, B.G., Parmley, W.W. Cardiac Glycosides & Other Drugs Used in Congestive Heart Failure. 8th Ed., New York, McGraw Hill, 200-218, 2001
20 Sack, R.B., Froehlich, J.L. Berberine inhibits intestinal secretory response of Vibrio chlerae and Escherichia coli enterotoxins. Infection and Immunity 35, 471-475, 1982
21 Reuter, H., Henderson, S.A., Han, T., Ross, R.S., Goldhaber, J.I., Philipson, K.D. The $Na^+-Ca2^+$ exchanger is essential for the action of cardiac glycosides. Journal of Cardiovascular Electrophysiology 12, 1295-1301, 2001   DOI   ScienceOn
22 Lehmann, H.D. Effect of plant glycosides on resistance and capacitance vessels. Arzneimittel-Forschung-Drug Research 34(4):423-429, 1984
23 Nishino, H., Kitagawa, K., Fujiki, H., Iwashima, A. Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. Oncology 43(2):131-134, 1986   DOI
24 Chun, Y.T., Yip, T.T., Lau, K.L., Kong, Y.C., Sankawa, U. A biochemical study on the hypotensive effect of berberine in rats. General Pharmacology 10(3), 177-182, 1979   DOI   ScienceOn
25 Hasenfuss, G., Pieske, B. Calcium cycling in congestive heart failure. Journal of Molecular and Cellular Cardiology 34, 951-969, 2002   DOI   ScienceOn
26 Lonn, E., Mckelvie, R. Drug treatment in heart failure. British Medical Journal 320, 1188-1192, 2000   DOI
27 Braunwald, E., Bristow, M.R. Congestive heart failure: fifty years of progress. Circulation 102, 14-23, 2000   DOI   ScienceOn
28 Smith, T.W., Artman, E.M., Friedman, P.L., Blatt, C.M., Marsch, J.D. Digitalis glycosides: mechanism and manifestation of toxicity. Progress in Cardiovascular Diseases 26, 495-540, 1984   DOI   ScienceOn
29 Leier, C.V., Binkley, P.F. Parenteral inotropic support for advanced congestive heart failure. Progress in Cardiovascular Diseases 41(3):207-224, 1998   DOI   ScienceOn
30 Kang, D.G., Sohn, E.J., Kwon, E.K., Han, J.H., Oh, H., Lee, H.S. Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels. Vascular Pharmacology 39(6):281-286, 2002   DOI   ScienceOn