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Effects of the Combined-administration of Acanthopanacis Cortex and Lycii Cortex Radicis on Immune Response  

Lee, Kyung-A (College of Pharmacy, Woosuk University)
Park, Hoon (College of Pharmacy, Woosuk University)
Kwon, Jin (Korea National College of Rehabilitation & Welfare)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.3, 2006 , pp. 657-662 More about this Journal
Abstract
Immunological activities of the combined-administration of Acanthopanacis Cortex and Lycii Cortex Radicis were examined in BALB/C mice. The 40% ethyl alcohol extract of Acanthopanacis Corter (AE) or the 40% ethyl alcohol extract of Acanthopanacis Coriex and Lycii Cortex Radicis (ALE) were administered p.o. once a day for 7 days, respectively. AE did not affect the viability of thymocytes, but ALE decreased the viability of thymocytes. ALE enhanced the viability of splenocytes increased by AE. Also, AE enhanced the population of cytotoxic T cell in thymocytes, and ALE enhanced the population of helper T cell compared with AE. Furthermore, AE increased the population of $Thy1^+$ cells in splenocytes, and increased the population of splenic $CD4^+$ cells. In addition, ALE enhanced the phagocytic activity which was decreased by AE ALE decreased the production of nitric oxide increased by AE in peritoneal macrophages. These results suggest that ALE enhance an immune-regulative action of AE.
Keywords
Acanthopanacis Cortex; Lycii Cortex Radicis; thymocytes; splenocytes; phagocytic activity; nitric oxide;
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