Browse > Article

Effect of Sopung-san on Contact Hypersensitivity induced by Repeat Elicitation of DNCB  

Park, Sook-Jahr (Department of prescription, College of Oriental Medicine, Daegu Hanny University)
Lee, Sang-Gon (Department of Ophthalmology and Otorhinolaryngology and Dermotology, College of Oriental Medicine, Daegu Hanny University)
Baek, Jung-Han (Department of Pediatries, College of Oriental Medicine, Daegu Hanny University)
Byun, Sung-Hui (Department of prescription, College of Oriental Medicine, Daegu Hanny University)
Kim, Sang-Chan (Department of prescription, College of Oriental Medicine, Daegu Hanny University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.3, 2006 , pp. 623-628 More about this Journal
Abstract
Sopung-san(SPS; prescription No. DO27), a herbal medicine prescribed by oriental hospital of Daegu fanny University, has been used as cure for pruritus and psoriasis. To evaluate anti-inflammatory effect of Sopung-san, we treated Sopung-san extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/C mouse. Sopung-san was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatment, but a mouse ear thickness was significantly reduced by Sopung-san after 2 weeks. treatment. Sopung-san reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by DNCB and/or Sopung-san treatment. $IL-1{\beta}$ and IL-6 from ear tissue were significantly increased by DNCB, Dut were not reduced by Sopung-san. From these results, anti-inflammatory effect of Sopung-san, especially reduction of ear swelling, might be partly due to reduction of IgG in serum.
Keywords
Sopung-san; Contact hypersensitivity; DNCB;
Citations & Related Records
연도 인용수 순위
  • Reference
1 정규만. 알레르기와 한방. 서울. 제일로. pp 90-92, 1990
2 Stricker, R.B., Elswood, B.F., Abrams, D.I. Dendritic cells and dinitrochlorobenzene (DNCB): a new treatment approach to AIDS. Immunol Lett. 29(3):191-196, 1991   DOI   ScienceOn
3 周珉. 過敏性疾病的中醫治療. 上海. 上海中醫藥大學出版社. pp 250-255, 1995
4 윤수영, 채병윤. 소풍산과 가미소풍산의 효능에 대한 실험적 연구. 경희의학. 5(2):129-141, 1989
5 이준성, 서형식, 노석선. 消風散加味의 抗알레르기 효과에 관한 실험적 연구. 대한외관과학회지. 14(2):9-20, 2001
6 강석영. 알레르기질환의 진단과 치료. 서울. 일조각. pp 253-254, 1993
7 Nakada, T., Watanabe, K., Matsumoto, T., Santa, K., Triizuka, K., Hanawa, T. Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen. Int Immunopharmacol. 2(7):901-911, 2002   DOI   ScienceOn
8 Farraj, A.K., Harkema, J.R., Kaminski, N.E. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicol Sci. 79(2):315-325, 2004   DOI   ScienceOn
9 ROB, C. AALBERSE. Specific IgE and IgG Responses in Atopic versus Nonatopic Subjects. Am J Respir Crit Care Med. 162:S124-127, 2000   DOI
10 권오성, 김진택, 박인식, 안상현, 이해풍, 김호현, 강윤호. 連翹敗毒散加味方이 알러지성 접촉 피부염에 미치는 영향. 동국대학교한의학연구소논문집. 8(1):77-91, 1999
11 Albers, R., Bol, M., Bleumink, R., Willems, A.A., Pieters, R.H. Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. Nutrition. 19(11-12):940-946, 2003   DOI   ScienceOn
12 서형식, 노석선. 소풍산의 Allergy 억제 효능에 관한 연구. 대한외관과학회지. 13(1):22-29, 2000
13 조세앙, 박성식. 凉膈散火湯이 Allergy성 접촉 피부염에 미치는 영향. 사상체질학회지. 13(3):89-101, 2001
14 Gawkrodger, D.J., Haftek, M., Botham, P.A., Carr, M.M., Spencer, M.J., Ross, J.A., Hunter, J.A., Thivolet, J. The hapten in contact hypersensitivity to dinitrochlorobenzene: immunoelectron microscopic and immunofluorescent studies. Dermatologica. 178(3):126-130, 1989   DOI   ScienceOn
15 김창환, 김경준. 양혈사물탕가미방이 Allergy성 접촉 피부염에 미치는 영향. 한방안이비인후피부과학회지. 18(1):13-26, 2005
16 김만식, 박성식. Allergy성 접촉 피부염이 유발된 백서의 손상피부에 熱多寒少湯 전탕액이 미치는 영향. 사상체질학회지. 14(3):97-113, 2002
17 G.J. Gleich, H. Kita. Bronchial asthma: Lessons from murine models. Proc. Natl. Acad. Sci. 94:2101-2102, 1997
18 권종훈, 신길조, 이원철. 梔子 추출물이 DNCB로 유도된 생쥐의 Allergy성 접촉 피부염에 미치는 영향. 대한한방내과학회지. 20(2):105-119, 1999
19 Hanau, D., Fabre, M., Schmitt, D.A., Lepoittevin, J.P., Stampf, J.L., Grosshans, E., Benezra, C., Cazenave, J.P. ATPase and morphologic changes in Langerhans cells induced by epicutaneous application of a sensitizing dose of DNFB. J Invest Dermatol. 92(5):689-694, 1989   DOI   ScienceOn
20 민영규, 최정화, 김종한, 박수연. 소풍산가미방과 외치방 병용이 NC/Nga 아토피 생쥐에 미치는 영향. 한방안이비인후피부과학회지. 18(1):116-134, 2005
21 신광식, 손정숙, 김동은, 전원준, 정승현, 신길조, 이원철. 生地黃 추출물이 DNCB로 유도된 생쥐의 Allergy성 접촉피부염에 미치는 영향. 방제학회지. 8(1):257-280, 2000
22 Miyajima, I., Dombrowicz, D., Martin, T.R., Ravetch, J.V., Kinet, J.P., Galli, S.J. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest. 99(5):901-914, 1997   DOI   ScienceOn
23 김찬중, 김윤범, 구영희, 남혜정. Allergy성 접촉피부염에 대한 고삼, 황련의 Iontophoresis 치료 효과. 한방안이비인후피부과학회지. 18(1):199-220, 2005
24 Delgado, A.V., McManus, A.T., Chambers, J.P. Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P. Neuropeptides. 37(6):355-361, 2003   DOI   ScienceOn
25 김호연, 김동환. 連翹敗毒散加味方이 알러지성 접촉 피부염에 미치는 영향 2- 알러지성 접촉 피부염 유발로 손상된 생쥐 상피세포 완화를 중심으로. 세명대학교 논문집. 13(3):67-81, 2001
26 김윤범. 접촉성 피부염에 대한 한방적 고찰. 대한외관과학회지. 5(1):113-120, 1992
27 Hill, S., Edwards, A.J., Kimber, I., Knight, S.C. Systemic migration of dendritic cells during contact sensitization. Immunology. 71(2):277-281, 1990
28 전재홍, 김현아, 강윤호. 접촉성 피부염에 관한 문헌적 고찰. 대한외관과학회지. 10(1):263-283, 1997
29 Lee, Y.S., Han, O.K., Park, C.W., Yang, C.H., Jeon, T.W., Yoo, W.K., Kim, S,H,, Kim, H.J. Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264.7 macrophage cells. J Ethnopharmacol. 100(3):289-294, 2005   DOI   ScienceOn
30 顧伯康. 實用中醫外科學. 北京. 上海科學技術出版社. 465-467, 1985
31 박성남, 정혁상, 이진용. 소풍산이 BALB/c mouse를 이용한 Atopy 피부염 Model에 미치는 영향. 경희의학. 20(2):129-141, 2004
32 Charles A Janeway, Paul Travers, Mark Walport, Mark Shlomchik. Immuobiology. Gerald. New York. pp 473, 481, 2001
33 대한피부과학회. 피부과학. 서울. 여문각. pp 166-174, 201, 2001
34 Bang, D., Nakagawa, S., Oka, D., Takei, Y., Jinno, Y., Ueki, H. The distribution of 2,4-dinitrophenyl groups on Thy-1 positive cells in the epidermis of mouse following skin painting with 2,4-dinitrochlorobenzene. J Dermatol. 15(1):27-31, 1988   DOI