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Experimental Study on the Suppression Effect of Asthma and Immune Response Improvement of Stemonae Radix Herbal-acupuncture  

Heo, Min (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Oh, Young-Seon (Hyehwa Hospital, Daejeon University)
Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Yoo, Ho-Rhyong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.3, 2006 , pp. 609-616 More about this Journal
Abstract
The aim of this study was to investigate the effect of SR-HA(Stemonae Radix-herbal acupuncture) at Joksamni(ST36) on ovalbumin-induced asthma in mice. C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). One of the two experimental groups was just treated with needle-prick on Joksamni(ST36) and the other group was treated with 1% concentrations of SR-HA at Joksamni(ST36) for the later 8 weeks (3times/week). The weight of lung of the mice group treated with SR-HA decreased significantly compared with those of control group, and significantly increased compared with those of normal group. The total cells of lung of the mice group treated with SR-HA decreased significantly compared with those of control group. Total leukocytes and eosinophils in BALF of the mice group treated wtih SR-HA decreased significantly compared with those of control group. Eosinophils in BALF of the mice group treated wtih SR-HA in Photomicrographs decreased significantly compared with those of control group. According to histological analysis of lung sections, adhesion of collagen in SR-HA decreased significantly compared with that of control group. The concentration of IgE, IL-4, IL-5 in BALF of the mice group treated with SR-HA decreased significantly compared with that of control group, and significantly increased compared with those of normal group. The concentration of IL-4, IL-5, IL-13 in serum of the mice group treated with SR-HA decreased significantly compared with that of control group, and significantly increased compared with those of normal group. The number of Gr-1+/CDl1b+, CO3-/CCR3+, CD4+, CD8+, CD3e+/CD69+ cells in the lungs of the mice group treated with SR-HA decreased significantly compared with those of control group. These results suggest that Stemonae Radix Herbal-acupuncture at Joksamni(ST36) in 057B146mice may be an effective part to OVA-induced asthma in C57BL/6 mice.
Keywords
SR(Stemonae Radix); herbal acupuncture; Asthma;
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1 全國韓醫科大學肺系內科學校室編著. 東醫肺系內科學. 서울, 문화사, p 320-346, 2002
2 鄭昇杞, 李珩九. 哮喘의 原因 및 治法에 關한 硏究. 大韓韓醫學會誌. 7(1):60-67, 1986
3 全國韓醫科大學本草學敎授編著. 本草學. 서울, 永林社, p 480, 1999
4 채우석. 면역질환의 한방개념과 치료에 대한 문헌적 고찰. 大韓韓醫學會誌. 11(25):55, 1990
5 신성찬. OVA-induced Asthma Model을 利用한 桑葉藥鍼의 喘息抑制效果에 對한 硏究. 대전대학교 대학원 석사학위논문. 2004
6 김세종. 면역학. 서울, 고려의학, p3,8,28,134,25-26,31-32, 1994
7 박영수. OVA-induced Asthma Mouse Model을 이용한 羌活藥鍼의 喘息에 관한 影響. 대전대학교 대학원 석사학위논문. 2004
8 陳良良, 李安生, 陶建寧, 陳衛星, 唐蓉芳. 足三里穴位免疫療法防治過敏性哮喘臨床及實驗硏究, 中國中西醫結合雜誌 16(12): 32-35, 1996.
9 鄭昇杞. 加味淸上補下湯이 喘息에 미치는 影響에 관한 實驗的 硏究. 서울, 大韓韓醫學會誌 12(1):118-138, 1991
10 고영률. 천식의 병태생리. 소아알레르기 및 호흡기. 10(4):255- 262, 2000
11 權純湖. 五拗湯이 allergy 喘息의 呼吸 樣相과 氣管 組織에 미치는 影響, 서울, 大韓韓醫學會誌, 20(2):98-107, 1999
12 Executive summary. Guidelines for the diagnosis and management of asthma. National Asthma Education Program Expert Panel Report II. U.S. Department of Health and Humen Services, Public Health Service National Institues of Health. 1997
13 Nicholas, W. Lukacs. Role of chemokines in the pathogenesis of asthma. Nature review:immunology. pp 108-116. 2001
14 김유영. 氣管支喘息의 최신 치료전략, 결핵 및 호흡기질환. 43(1):1, 1996
15 全國韓醫科大學 鍼灸經穴學敎室. 鍼灸學(上,下). 서울, 集文堂, pp 214-234, 382, 384, 730-732, 1988. 1991
16 송민식. 沙蔘 藥鍼의 喘息抑制 및 免疫調節效果에 對한 實驗的 硏究. 대전대학교 대학원 석사학위논문. 2004
17 전국의과대학 임상교수편. 임상진단학. 서울, 한미의학, pp 392-393, 2002
18 Abul, K. Abbas, Andrew H. Lichtman. 세포분자면역학. 강재성 譯. 서울, 범문사, pp 477-522, 2004
19 김승수, 정희재, 정승기, 이형구. 解表二陳湯이 allergy喘息의 呼吸樣相과 氣管組織에 미치는 影響. 대한한방내과학회지 19(2):59-73, 1999
20 성호경. 생리학. 5판. 서울, 醫學文化社, pp 94-106, 1991
21 한용철. 臨床呼吸器學. 서울, 일조각, pp.208-209, 1994
22 李淵台. 最新免疫學. 서울, 集文堂, pp 1-35, 52-53, 76, 81, 88, 1985
23 이동생, 정희재, 정승기, 이형구. 麥門冬과 五味子가 Asthma model內의 Cytokine IL-4, IL-5, IL-6에 미치는 影響. 경희의학 16(2):69-80, 2000
24 Corrigan, C.J., Hamid, Q., North, J., Barkans, J., Moqbel, R., Durhams, S., Gemou-Engesaeth, V., Kay, A.B : Peripheral Blood CD4 but not CD8 T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survivalin the context of a Th2- type pattern : Effect of glucocorticoid therapy. Am. J. Respir. Cell Mol Biol, 12, 567, 1995   DOI   ScienceOn
25 許 浚. 東醫寶鑑. 서울, 南山堂, p.145, 474-480, 1998
26 Ivan Roitt 외. Immunology 6th. Mosby, Newyork, pp 125-127, 2002
27 김일구. 細辛藥鍼의 喘息抑制 및 免疫調節效果에 對한 實驗的 硏究. 대전대학교 대학원 석사학위논문. 2004
28 Ivan Roitt. Essential immunology 9th, Blackwell science, U.S.A. pp 179-200, 151-167, 1994
29 巢元方. 諸病源候論(卷13,14). 서울, 大星文化社, pp106-117, 1992
30 李珩九. 五拗湯이 咳嗽, 喘息에 미치는 影響. 서울, 慶熙大學校大學院, p 175-190, 1982
31 김보균. 升麻藥鍼의 喘息 및 免疫에 미치는 實驗的 硏究. 대전대학교 대학원 석사학위논문. 2004