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Acute Oral Toxicity of Dangguibohyel-tang in ICR Mice  

Kang, Soon-Ah (Department of Fermented Food Science, Seoul University of Venture & Information)
Chang, Mun-Seog (Department of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School)
Oh, Myung-Sook (College of Oriental Medicine, Kyung Hee University)
Park, Wan-Su (College of Oriental Medicine, Kyung Hee University)
Kang, Ji-Wung (College of Oriental Medicine, Kyung Hee University)
Kim, Won-Nam (College of Oriental Medicine, Kyung Hee University)
Yang, Woong-Mo (College of Oriental Medicine, Kyung Hee University)
Lee, Byong-Hee (College of Oriental Medicine, Kyung Hee University)
Bae, Oh-Sung (Department of Natural Healing Science, Dong Bang University)
Park, Seong-Kyu (College of Oriental Medicine, Kyung Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.3, 2006 , pp. 572-574 More about this Journal
Abstract
The Dangguibohyel-tang (DBT) was used to treat anemia in traditional Korean medicine. Acute oral toxicity of DBT was studied in ICR mice. ICR mice were administered orally with dosages of 100 mg/kg (low dosage group), 200 mg/kg (middle dosage group), and 400 mg/kg (high dosage group) of DBT. We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. DBT did not show any toxic effect in ICR mice and oral LD50 value was over 400 mg/kg in ICR mice.
Keywords
Dangguibohyel-tang (DBT); acute toxicity; $LD_{50}$; body weights; clinical signs;
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Times Cited By KSCI : 1  (Citation Analysis)
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