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Evaluation of Korean Phytomedicinal Plants on inhibition of Prostaglandin $E_2\;(PGE_2)$ Production and Cyclooxygenase-2 (COX-2) in LPS-stimulated U937 Cells  

Jang, Seon-Il (Division of Beauty Design, School of Human Environment, Wonkwang University)
Jun, Chang-Soo (Department of Skin & Beauty, Seojeong College)
Kwak, Kyung-Chell (Department of Skin & Beauty, Seojeong College)
Bae, Moon-Sung (Department of Skin & Beauty, Seojeong College)
Lee, Jung-Ho (Department of Skin & Beauty, Seojeong College)
Kim, Ki-Young (Department of Oriental medical prescription, Wonkwang University)
Yun, Yong-Gab (Department of Bionanochemistry, College of Natural Science, Wonkwang University)
Chai, Gyu-Yun (Department of Skin & Beauty, Seojeong College)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.2, 2006 , pp. 455-459 More about this Journal
Abstract
The inhibitors of prostaglandin $E_2\;(PGE_2)$ production and cyclooxygenase-2 (COX-2) activity have been considered as potential anti-inflammatory agents. In this study, we evaluated 9 compounds isolated from 5 Korean phytomedicinal plants (Spirea prunifolia, Paeonia suffruticosa, Salvia miltiorrhiza, Scutellaria baicalensis, and Artemisia capillaris) for the inhibition of $PGE_2$production and COX-2 expession in lipopolysaccharide (LPS)-stimulated human macrophages U937 cells. As a result, several compound such as prunioside A, penta-O-galloyl-beta-D-glucose, tanshinone IIA, baicalin, baicalein, wogonin, scopolatin, scoparone and decursinol showed potent inhibition of $PGE_2$production (50-70% inhibition at the test concentration of $10\;{\mu}M$). In addition, these compounds were also considered as potential inhibitors of COX-2 activity (45-73% inhibition at the test concentration of $10\;{\mu}M$). These active compound mediating COX-2 inhibitory activities are warranted for further elucidation of active principles for development of anti-inflammatory agents and these properties may contribute to the anti-atopic dermatitis activity.
Keywords
cyclooxygenase-2 (COX-2); prostaglandin E2 (PGE2); U937 cells; phytomedicinal plants; anti-inflammatory agents;
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