Browse > Article

Experimental Studies on Hair Growth Effect of Extracts of Cortex Mori Radicis in Hair Removed C57BL/6N Mice  

Na, Hyun-Uk (Department of Pathology, College of Oriental Medicine, Woosuk University)
Lee, Moon-Won (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Jeong, Han-Sol (Department of Pathology, College of Oriental Medicine, Woosuk University)
Kwon, Jin (Department of Prosthetics & Othotics, Korea National College of Rehabilitation & Welfare)
Lee, Kwang-Gyu (Department of Pathology, College of Oriental Medicine, Woosuk University)
Lee, Chang-Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.2, 2006 , pp. 428-435 More about this Journal
Abstract
Cortex Mori radicis has been used as a components of antidiabetics, antiasthma and diuresis in Oriental Medicine. This experiment examined the effect of an extracts, obtained from the acetone(CM-A) and aqueous(CM-W) extracts of Cortex Mori radicis, on hair growing activity of the C57BL/6N mice after topical application to skin. We investigated the number of hair follicle and mast cells, and changes of subpopulation of splenocytes and thymocytes in skin for 16 day. The results were as follows : The Hair growing effect in experimental groups was more increased in 85%(CM-A) and 90%(CM-W) than control group(10%) in hair depilated area. The number of hair follicle in experimental groups(CM-A and CM-W) was more increased than control group. Splenic B/T lymphocytes of CM-A group were decreased compare to control group. CD4/CD8 positive TH cells in splenic T lymphocytes of CM-W group were increased compare to control group. These results suggest that CM-A and CM-W may be used in treatment of alopecia areata.
Keywords
Cortex Mori radicis; hair growing activity; mast cells; immune reaction;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Muller, H.K., Rook, A.J., Kubba, R. Immunohistology and autoantibody studies in alopecia areata. Br J Dermatol 102:609-610, 1980   DOI   ScienceOn
2 Bergfeld, W. Diffuse hair loss in women. Cutis 22:190-195, 1987
3 김봉태, 홍성우, 장발보(102-A)의 탈모증 환자 국소 도포한 치료효과에 대한 고찰. 최신의학, 31(1):125, 1988
4 金達鎬, 黃帝內經注解補注素問, 素問.上古天眞論, 醫聖堂, p 14, 2001
5 金達鎬, 黃帝內經注解補注素問, 素問.上古天眞論, 醫聖堂, p 18, 2001
6 丁光迪, 諸病源候論校注, 人民衛生出版社, p 765, 1991
7 吳謙, 醫宗金鑑(下卷), 人民衛生出版社), p 1660, 1982
8 임사비나, 최규동, 김수경. 탈모에 대한 동서의학적 고찰. 경산대학교 제한동의학술원 논문집 4(1):699-710, 1999
9 송순기, 이명종. 안드로겐성 탈모증의 두피재활에 관한 문헌적 고찰. 한의정보학회지 5(1):162-176, 1999
10 歐陽忠興, 中醫呼吸病學, 中國醫藥科技出版社, pp 120-121, 1995
11 Chung, K.O., Kim, B.Y., Lee, M.H., Kim, Y.R., Chung, H.Y., Park, J.H., Moon, J.O. In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L.. J Pharm Pharmacol 55(12):1695-1700, 2003   DOI   ScienceOn
12 Kim, E.S., Park, S.J., Lee, E.J., Kim, B.K., Huh, H., Lee, B.J. Purification and characterization of Moran 20K from Morus alba. Arch Pharm Res 22(1):9-12, 1999   DOI
13 金達鎬, 黃帝內經注解補注素問, 素問․五藏生成論, 醫聖堂, p 234, 2001
14 중약대사전 편찬위원회, 中藥大辭典, 정담. p 2158-2159, 1999
15 陳貴廷, 實用中醫結合診斷治療學, 一中社, p 1508, 1992
16 Kim, H.M., Han, S.B., Lee, K.H., Lee, C.W., Kim, C.Y., Lee, E.J., Huh, H. Immunomodulating activity of a polysaccharide isolated from Mori Cortex Radicis. Arch Pharm Res 23(3):240-242, 2000.   DOI
17 金達鎬, 黃帝內經注解補注素問, 素問․痿論, 醫聖堂, p 908, 2001
18 Paus, R., Bottge, JA., Henz, B.M., Maurer, M. Hair growth control by immunosuppression. Arch Dermatol Res 288:408-410, 1996   DOI   ScienceOn
19 金達鎬, 黃帝內經注解補注素問, 素問.五藏生成論, 醫聖堂, p 236, 2001
20 楊思澍, 中醫臨床大全, 大星出版社, p 912, 1988
21 金達鎬, 黃帝內經注解補注素問, 素問.陰陽應象大論, 醫聖堂, p 128, 2001
22 김소영, 김중호, 채병윤. 탈모에 응용되는 神應養眞丹의 효능에 관한 실험적 연구. 외관과학회지 4(1):43-58, 1991
23 이희삼, 문재유. Cytarabine으로 유도된 탈모증에 대한 상백피 추출물의 육모촉진 효과. 약학회지 44(1):66-70, 2000
24 Shortman, K., Backson, H. The differentiation of T lymphocytes. I. Proliferation kinetics and interrelationships of subpopulations of mouse thymus cells. Cell Immunol 12:230-246, 1974   DOI   ScienceOn
25 蔡永敏, 最新中藥藥理與臨床應用, 華夏出版社, p 376, 1999
26 葛洪, 肘後備急方, 中國醫學大系 734권, 商務印書館, p 500
27 노현찬, 노석선. 苦蔘추출물이 모발성장 촉진 및 면포억제에 미치는 영향. 대한안이비인후피부과학회지 15(1):96-126, 2002
28 丁光迪, 諸病源候論校注, 人民衛生出版社, p 772, 1991
29 鄭虎占, 董澤宏, 余靖. 中藥現代硏究與應用, 제4권, 학원출판사, p.3871, 1998
30 Paus, R., Handjiski, B., Czarnetzki, B.M., Eichimuller, S. A murine model for inducing and manipulating hair follicle regression(catagen): effects of dexamethasone and cyclosporin A. J Invest Dermatol 103:143-147, 1994   DOI   ScienceOn
31 최근희 외 11인, 모발과학, 수문사, pp 36-38, 138-140, 2001
32 홍석훈, 노석선. 모발탈락의 병인 및 치료법에 대한 문헌적 고찰. 외관과학회지 9(1):43-65, 1996
33 金達鎬, 黃帝內經注解補注素問, 素問.五藏生成論, 醫聖堂, p 236, 2001
34 Taylor, M., Ashcroft, A.T., Messenger, A.G. Cyclosporin A prolongs human hair growth in vitro. J Invest Dermatol 100:237-239, 1993   DOI   ScienceOn
35 고재승 외 19인. 인체발생학, 5판, 정문각, p 483, 1996
36 Selmanowilz, V., Victor, S., Warburton, D., Orentreich, N. Fingerprints arches in alopecia areata. Arch Dermatol 110:570-571, 1974   DOI   ScienceOn
37 丁光迪, 諸病源候論校注, 人民衛生出版社, p 763, 1991
38 이희삼, 윤성중, 문윤기, 문재유. 탈모증에 대한 상백피 복합물의 모발성장 효과. 한잠학지 42(2):83-85, 2000
39 Friedman, P.S. Alopecia areata and auto-immunity. Br J Dermatol 105:153-157, 1981   DOI   ScienceOn
40 Oh, H., Ko, E.K., Jun, J.Y, Oh, M.H,, Park, S.U., Kang, K.H., Lee, H.S., Kim, Y.C. Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. Planta Med 68(10):932-934, 2002   DOI   ScienceOn
41 陳實功, 外科正宗, (中華經典醫書 第六集), 中國醫藥科學技術出版社, p 987, 2002
42 Toback, C., Ajkunar, S. The emotional disturbances underlying alopecia areata, alopecia totalis and trichotillomania. Child Psychiatry Hum Dev 10:114-117, 1979   DOI   ScienceOn