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Protective Effects of Iljungbogan-Tang on Acute Hepatotoxicity Induced by $CCL_4$ and Acetaminophen  

Kim, Joon-Myoung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Park, Yang-Chun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Son, Gi-Jung (Il Jung Oriental medicine clinic)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.2, 2006 , pp. 410-413 More about this Journal
Abstract
This study was done to investigate the protective effects of Iljungbogan-Tang on acute hepatotoxicity of rats induced by $CCL_4$ and acetaminophen. The subject animals were divided into 3 groups : control group(administrated 0.5% carboxymethyl cellulose), sample group(30, 100, 300, 600mg/kg administrated), positive control group (administrated silymarine), Acute hepatotoxicity of rats were induced by $CCL_4$ and acetaminophen, and the serum transaminase(AST, ALT) were measured for enzyme activities. The inhibitory effects on the serum AST activities were noted in sample group(100, 300, 600mg/kg administrated) on hepatotoxicity of rats induced by $CCL_4$. The inhibitory effects on the serum AST, ALT activities were noted in sample group(30mg/kg administrated) on hepatotoxicity of rats induced by acetaminophen. The inhibitory effects on the serum AST activities were noted in sample group(600mg/kg single dose administrated) on hepatotoxicity of rats induced by acetaminophen. It is considered that Iljungbogan-Tang has protective effects against hepatotoxicity in rats induced by $CCL_4$ and acetaminophen. So it is required to study about the actions of mutual relation of medicines and patho-mechanism through experiment.
Keywords
Iljungbogan-Tang; hepatotoxicity; $CCL_4$; acetaminophen;
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