Browse > Article

Effect of Rhizoma Zingiberis Siccatum Extract on the Induction of HL-60 Human Leukemia Cell Differentiation  

Oh, Yu-Mi (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Ju, Seong-Min (Department of Pathology, College of College of Oriental Medicine, Wonkwang University)
Kim, Young-Mi (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Yun, Yong-Gab (Department of Prescription, College of Oriental Medicine, Wonkwang University)
Jeon, Byung-Hun (Department of Pathology, College of College of Oriental Medicine, Wonkwang University)
Kim, Won-Sin (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.2, 2006 , pp. 345-351 More about this Journal
Abstract
We have examined the induction of HL-60 cell differentiation by treatment of the water extract of Rhizoma Zingiberis Siccatum, which is a Korean traditional herbal medicine. It was observed that HL-60 cell proliferation was dose-dependently inhibited by treatment with various dose of Rhizoma Zingiberis Siccatum extract. The level of inhibition was identical to those of ATRA-treated cells. Rhizoma Zingiberis Siccatum extract treatment caused a significant change in NBT reduction (47%) and enhanced ATRA-induced NBT reduction. Treatment of Rhizoma Zingiberis Siccatum to HL-60 cells increased only CD11 b expression in the cells, and also increased markedly G0/G1 stage arrest. This can suggest that Rhizoma Zingiberis Siccatum induced the differentiation of HL-60 cell and enhanced ATRA-induced differentiation predominantly along the granulocytic lineage. The results present here show that Rhizoma Zingiberis Siccatum extract contains the potential effect of differentiation induction or acts as a agent enhancing the induction of differentiation.
Keywords
Differentiation; HL-60; ATRA; Rhizoma Zingiberis Siccatum;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Collins, S.J. The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood. 70, 1233-1244, 1987
2 Datto, M.B., Li, Y., Panus, J.F., Howe, D.J., Xiong, Y., Wang, X.F. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA. 92, 5545-5549, 1995
3 Lee, K.H., Chang, M.Y., Ahn, J.I., Yu, D.H., Jung, S.S., Choi, J.H. Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells, NB4 and HL-60 cells. Biochem. Biophys. Res. Commun. 296, 1125-1133, 2002   DOI   ScienceOn
4 Newburger, P.E., Chovaniec, M.E., Greenberger, J.S., Cohen, H.J. Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation. J. Cell Biol. 82, 315-322, 1979   DOI   ScienceOn
5 James, S.Y., Williams, M.A., Kelsey, S.M., Newland, A.C., Colston, K.W. The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells. Biochem. Pharmacol. 54, 625-634, 1997   DOI   ScienceOn
6 Schwaller, J., Koeffler, H.P., Niklaus, G., Loetscher, P., Nagel, S., Fey, M.F., Tobler, A. Posttranscriptional stabilization underlies p53-independent induction of $p21^{WAF1/CIP1/SDI1}$ in differentiating human leukemic cells. J. Clin. Invest. 95, 973-979, 1995   DOI
7 hu, B., Zhang, L.H., Zhao, Y.M., Cui, J.R., Strada, S.J. 8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)/G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated $p21^{(WAF1/CIP1)}$. J. Cell Biochem. 2005
8 Sachs, L. Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: a model for the origin and progression of malignancy. Proc. Natl. Acad. Sci. USA. 77, 6152-6156, 1980
9 Horie, N., Mori, T., Asada, H., Ishikawa, A., Johnston, P. G., Takeishi, K. Implication of CDK inhibitors p21 and p27 in the differentiation of HL-60 cells. Biol. Pharm. Bull. 27, 992-997, 2004   DOI   ScienceOn
10 Chung, T.W., Choi, H.J., Lee, Y.C., Kim, C.H. Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells. Glycobiology. 15, 233-244, 2005   DOI   ScienceOn
11 Tsiftsoglou, A.S., Pappas, I.S., Vizirianakis, I.S. Mechanisms involved in the induced differentiation of leukemia cells. Pharmacol. Ther. 100, 257-290, 2003   DOI   ScienceOn
12 Kong, G., Lee, S.J., Kim, H.J., Surh, Y.J., Kim, N.D. Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by 2-(allylthio) pyrazine. Cancer Lett. 144, 1-8, 1999   DOI   ScienceOn
13 Bestilny, L.J., Riabowol, K.T. A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells. Exp. Cell Res. 256, 264-271, 2000   DOI   ScienceOn
14 Camarasa, M.V., Castro-Galache M.D., Carrasco-Garcia, E., Garcia-Morales, P., Saceda, M., Ferragut, J.A. Differentiation and drug resistance relationships in leukemia cells. J. Cell Biochem. 94, 98-108, 2005   DOI   ScienceOn
15 Hickstein, D.D., Back, A.L., Collins, S.J. Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation. J. Biol. Chem. 264, 21812-21817, 1987
16 Hickstein, D.D., Baker, D.M., Gollahon, K.A., Back, A.L. Identification of the promoter of the myelomonocytic leukocyte integrin CD11b. Proc. Natl. Acad. Sci. USA. 89, 2105-2109, 1992
17 Huang, W.W., Yang, J.S., Lin, C.F., Ho, W.J., Lee, M.R. Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells. Leuk. Res. 29, 685-692, 2005   DOI   ScienceOn
18 Degos, L., Dombret, H., Chomienne, C., Daniel, M.T., Miclea, J.M., Chastang, C., Castaigne, S., Fenaux, P. All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. Blood. 85, 2643-2653, 1995
19 Prall, O.W., Sarcevic, B., Musgrove, E.A., Watts, C.K., Sutherland, R.L. Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J. Biol. Chem. 272, 10882-10894, 1997   DOI   ScienceOn
20 Gianni, M., Ponzanelli, I., Mologni, L., Reichert, U., Rambaldi, A., Terao, M., Garattini, E. Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases. Cell Death Differ. 7, 447-460, 2000   DOI   ScienceOn
21 Mishima, S., Inoh, Y., Narita, Y., Ohta, S., Sakamoto, T., Araki, Y., Suzuki, K.M., Akao, Y., Nozawa, Y. Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells. Bioorg. Med. Chem. 13, 5814-5818, 1995   DOI   ScienceOn
22 Drayson, M.T., Michell, R.H., Durham, J., Brown, G. Cell proliferation and CD11b expression are controlled independently during HL60 cell differentiation initiated by 1,25 alpha-dihydroxyvitamin D(3) or all-trans-retinoic acid. Exp. Cell Res. 266, 126-134, 2001   DOI   ScienceOn
23 Pae, H.O., Seo, W.G., Kim, N.Y., Oh, G.S., Kim, G.E., Kim, Y.H., Kwak, H.J., Yun, Y.G., Jun, C.D., Chung, H.T. Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by water-soluble chitosan oligomer. Leuk. Res. 25, 339-346, 2001   DOI   ScienceOn
24 Breitman, T.R., Selonick, S.E., Collins, S.J. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl. Acad. Sci. USA. 77, 2936-2940, 1980
25 Roberts, P.J., Khwaja, A., Lie, A.K., Bybee, A., Yong, K., Thomas, N.S., Linch, D.C. Differentiation-linked changes in tyrosine phosphorylation, functional activity, and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor. Blood. 84, 1064-1073, 1994
26 Makishima, M., Umesono, K., Shudo, K., Naoe, T., Kishi, K., Honma, Y. Induction of differentiation in acute promyelocytic leukemia cells by 9-cis retinoic acid alpha-tocopherol ester (9-cis tretinoin tocoferil). Blood. 91, 4715-4726, 1998
27 Yang, L., Zhao, H., Li, S. W., Ahrens, K., Collins, C., Eckenrode, S., Ruan, Q.G., McIndoe, R.A., She, J. X.Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells. J. Mol. Diagn. 5, 212-221, 2003   DOI   ScienceOn
28 Noble, J.M., Ford, G.A., Thomas, T.H. Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes. Clin. Sci. 97, 323-329, 1999   DOI   ScienceOn
29 Brown, G., Drayson, M.T., Durham, J., Toellner, K.M., Hughes, P.J., Choudhry, M.A., Taylor, D.R., Bird, R., Michell, R.H. HL60 cells halted in G1 or S phase differentiate normally. Exp. Cell. Res. 281, 28-38, 2002   DOI   ScienceOn