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Effect of Genistein on Chemopreventive Activity of Human Brest Cancer  

Shon Yun-Hee (Intractable Diseases Research Center and Cardiovascular Medical Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Kim Ho-Chang (Intractable Diseases Research Center and Cardiovascular Medical Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Nam Kyung-Soo (Intractable Diseases Research Center and Cardiovascular Medical Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.1, 2006 , pp. 88-92 More about this Journal
Abstract
Genistein was tested for chemopreventive potential against breast cancer by measuring the effect on proliferation of human breast cancer cells, human placental aromatase activity and cyclooxygenases-2 (COX-2) expression and activity, Genistein inhibited the growth of estrogen-independent MDA-MB-231 human breast cancer cell. However, there is no inhibitory effect of genistein on human placental aromatase activity. The expression of COX-2 was inhibited by genistein in Western blot analysis. Genistein significantly inhibited COX-2 activity at the concentrations of 10 (p<0.05), 25 (p<0.05) and 50 ${\mu}M$ (p<0.01). These results suggest that genistein may have breast cancer chemopreventive potential by inhibiting the growth of human breast cancer cell and expression and activity of COX-2.
Keywords
Genistein; aromatase; cyclooxygenase-2; breast cancer chemoprevention;
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