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Effects of ChongMyung-Tang and SansaChongMyung-Tang Extract on the Alzheimer's Disease Model Induced dy CT105  

Lee Sang-Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Jung In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.1, 2006 , pp. 138-148 More about this Journal
Abstract
This research investigated the effect of the CMT and SCMT on Alzheimer's disease. The effects of the CMT and SCMT extract on expression of proinflammatory cytokine(IL-$1{\beta}$, IL-6, TNF-$\alpha$) in the THP-1 cell; amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT105; the AChE activity and the APP production of PC-12 cell lysate treated with CT105 were investigated. The CMT and SCMT extract suppressed overexpression of IL-$1{\beta}$, IL-6, TNF-$\alpha$ in the THP-1 cell treated dy LPS; the expression of APP, AChE mRNA in PC-12 cells treated with CT105; the AChE activity and the production of APP in PC-12 cell Iysate treated with CT105 significantly. This study suggest that CMT and SCMT may be effective for the prevention and treatment of Alzheimer's disease.
Keywords
ChongMyung-Tang(CMT); SansaChongMyung-Tang(SCMT); Dementia; Alzheimer's disease; CT105; cytokine;
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