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Protective Effect of Rehmannia Radix Preparata Extract on the Cisplatin-induced Cytotoxicity of HEI-OC1 Cells via Scavenging of Free Radicals  

Yu Hyeon-Hee (Department of Food and Nutrition, Kunsan National University)
Seo Se-Jeong (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
Kim Yeon-Hwa (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
Park Rae-Kil (Vestibulocochlear Research Center & Department of Microbiology, School of Medicine, Wonkwang University)
So Hong-Seob (Vestibulocochlear Research Center & Department of Microbiology, School of Medicine, Wonkwang University)
Jeon Byung-Hun (Department of Oriental Pathology, College of Oriental Medicine, Wonkwang University)
Shin Mee-Kyung (Department of Food and Nutrition, Wonkwang University)
Jung Su-Young (Department of Food and Nutrition, Wonkwang University)
Kim Ki-Young (Department of Beauty Design, Wonkwang University)
You Yong-Ouk (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.5, 2005 , pp. 1349-1355 More about this Journal
Abstract
The steamed root of Rehmannia glutinosa has been used for treatment of inner ear diseases, such as tinnitus and hearing loss in traditional Oriental Medicine. In the present study, we investigated the effect of ethanol extract of steamed root R. glutinosa (SRG) on cisplatin cytotoxicity of HEI-OC1 auditory cells. In addition, to investigate the mechanism of SRG on cisplatin cytotoxicity, the effects of SRG on lipid peroxidation as well as scavenging activities against various free radicals were measured in cisplatin-treated cells. Treatment of SRG protected cells from cisplatin and reduced lipid peroxidation in a dose-dependent manner. Furthermore, SRG demonstrated significant scavenging activity against various free radicals, including superoxide radical, hydroxyl radical, hydrogen peroxide, and DPPH radical. These results indicate that SRG protects cisplatin-induced damages of HEI-OC1 cells through inhibition of lipid peroxidation and augmenting scavenging activities against free radials.
Keywords
Rehmannia glutinosa; HEI-OC1 cell; Cisplatin; Reactive oxygen species; Free radical;
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