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Effects of Samreungjeon on the Proliferation of Transplanted-L1210 Cells in Mice  

Jeon Yong Keun (College of Pharmacy, Woosuk Univesity)
Leem Jae Yoon (College of Pharmacy, Woosuk Univesity)
Song Jung Mo (College of Oriental Medicine, Woosuk University)
Eun Jae Soon (College of Pharmacy, Woosuk Univesity)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.4, 2005 , pp. 960-964 More about this Journal
Abstract
We studied effects of Samreungjeon water extract (SE) on the proliferation of transplanted-L1210 cells to mice. Samreungjeon is composed of Scirpi Tuber, Zedoariae Rhizoma, Aurantii immaturi Pericarpium, Pinelliae Tuber and Hordei Fructus Germinatus. When SE (500 mg/kg) was administered orally once a day for 7 days after transplantation of L1210 cells to mice, the proliferation of transplanted-L1210 cells was decreased and DNA fragmentation of transplanted-L1210 cells was induced. Also, DNA fragmentation of L1210 cells was enhanced by co-culture with the peritoneal macrophages obtained from SE-administered mice and was partly inhibited by L-NMMA in vitro. SE enhanced the production of nitric oxide from murine peritoneal macrophages in vitro and in vivo. These results suggest that SE partly induces apoptosis of transplanted-L1210 cells via production of nitric oxide from macrophages.
Keywords
Samreungjeon; L1210 cells; apoptosis; nitric oxide;
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