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Antitumor and Anti-metastatic Effect of Mineral Powder  

Song Gyu Yong (Oriental Medical College, Daejon University)
Bae Ki Whan (Oriental Medical College, Daejon University)
Myung Chang-Seon (Oriental Medical College, Daejon University)
Jin Wen Yi (College of Pharmacy, Chungnam National University)
Park Yong Jin (Baeknam Oriental Medical Hospital)
Yun Mi Young (Oriental Medical College, Daejon University)
Kim Dong Hee (Oriental Medical College, Daejon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.4, 2005 , pp. 1011-1015 More about this Journal
Abstract
Antitumor and anti-metastatic effects of mineral powder(MP) were studied. In the present study, MP did not exhibit the any cytotoxic activity against leukemic cells such as L1210 and U937 tumor cell lines in vitro. Also, MP did not exhibit the any cytotoxic activity against solid cells such as A549 and B16-BL6 tumor cell lines in vitro. However, in vivo, MP exhibit a significant antitumor activity in BDF1 mice bearing Lewis lung carcinoma cells(LLC) with inhibition rates of 46 and $23\%$ at 200 and 100 mg/kg/day, respectively. Furthermore, in pulmonary colonization assay, MP exhibit the inhibitory effect of tumor metastasis. From these results, it was concluded that MP had antitumor and anti-metastatic activity suggesting its application for the prevention and treatment of cancer.
Keywords
Mineral powder; anti-metastatic activity; antitumor activity;
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