[KSCI] Korea Science Citation Index Service

Synthesis and Biological Activity of Geranyloxy Compounds

Oh, Hyun-Ju (Department of Beauty Art, Honam University)
Oh, In-Kio (Department of Cosmetic Science, Wonkwang Health Science College)
Na, Young-Soon (Department of Beauty, Konyang University)
Kim, Myung-Ju (Department of Skin & Beauty, Kwangju Health Science College)
Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences, Wonkwang University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.19, no.3, 2005 , pp. 792-796 More about this Journal

Abstract

Disk assays on the compounds (10 and 12) showed both to have antifungal activity against the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (1 and 3 mm inhibition zones at $60\;{\mu}g/disc$ ), but not against the Gram-positive bacterium B. subtilis or the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa or fungi Cladosporium resinae and Candida albicans. However, the compound (13) did not show against antifungal activity. The geranyloxy compounds (10, 12, and 13) were cytotoxic to P388 murine leukaemia cells ATCC CCL 46 P388D1, ( $IC_50$ >6,250 ng/mL at $7.5\;{\mu}g/disc$ ). These results suggest that The geranyloxy compounds possesses antimicrobial and antitumor activities.

Keywords

Trichophyton mentagrophytes; Antifungal activity;

Citations & Related Records

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