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Morphological Studies on Hair Growth Effect of Samultang-gamibang  

Kwon, Gang-Joo (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Chang-Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Lee, Moon-Won (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Choi, Doo-Ho (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Hak-Jae (Department of Prescriptionology, College of Oriental Medicine, Sangji University)
Kim, Ho-Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.3, 2005 , pp. 696-704 More about this Journal
Abstract
This experiment examined the effect of Samultang-gamibang (SGB) on hair growth in spontaneous alopecia areata C57BL/6N mice. We first investigated hair growth effect of SGB compare to control groups after apply to oral administration for 10 weeks and regional treatment in skin for last 4 weeks. We second investigated the number of hair follicle and mast cells after treatment of SGB in spontaneous alopecia areata C57BL/6N mice for 10 weeks. We third investigated immunoreactive density of neuropeptides in skin of spontaneous alopecia areata C57BL/6N mice by immunohistochemical methods. The results were as follows : Hair growing effect of experimental group was observed from 7 weeks after administration of SGB (87.5%). In experimental group, the number of mast cells and eosinophils was significantly decreased compare to control group. Immunoreactive density of substance P and corticotropin releasing factor (CRF) in skin of experimental group was weakly stained in epidermis and subcutaneous tissue compare to control group. Immunoreactive density of CRF-receptor (CRF-R), CRF-binding protein (CRF-BP) in skin of experimental group was increased in epidermis, sebaceous gland, inner root sheath, outer root sheath and secondary hair germ epithelium compare to control group. These results suggest that SGB may be used in treatment of alopecia areata.
Keywords
Samultang-gamibang(SGB); alopecia areata; hair; neuropeptides;
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