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Effect of Black Raspberry Wine to Testosterone in Sprague-Dawley Rats Administrated with Methoxychlor  

Lee, Sung-Il (Toyama Medical and Pharmaceutical University)
Whang, In-Soo (Chonbuk National University)
Hur, Jin (Chonbuk National University)
Lim, Chae-Woong (Chonbuk National University)
Ju, Sung-Min (College of Oriental Medicine, Wonkwang University)
Jeon, Byung-Hun (College of Oriental Medicine, Wonkwang University)
Baek, Byeong-Kirl (Chonbuk National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.3, 2005 , pp. 656-661 More about this Journal
Abstract
The study was conducted to investigate per oral (PO) effects of Black raspberry wine on testosterone levels in Sprague-Dawley rats oral administrated with Methoxychlor in order to establish the experimental clinical model for evaluating the influences on the sexual hormones of SD-Rat administrated with Methoxychlor(MET), it was dissolved in acetone and olive oil (1:19), which was administrated orally at doses of 200mg/kg body weight/ day for 7days. Black raspberry wine of 13% alcohol concentration, was prepared from ripen fruits of Rubus coreanus fermented with Saccharomyces cervisiae. PO administration of Black raspberry wine for 15 week produced dramatic increases of serum testosterone levels. Increase in the testosterone level was observed, using gamma counter with 125I testosterone, starting from 1 week post administration. Maximum increase in testosterone level was observed at 4 week post administration, 5.18${\pm}$0.76ng/mL, which was 10.1 times higher than before and at 15 weeks post administration it was recorded as 1.67${\pm}$0.19ng/mL indicating Black raspberry wine as an effective phyto-testosteronic beverage of the future.
Keywords
Black raspberry wine; rat; testosterone; Rubus coreanus wine; Methoxychlor;
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