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Effects of Black Raspberry Wine on Testosterone Level of New Zealand White Rabbits  

Lim, Chae-Woong (College of Veterinary Medicine, Chonbuk National University)
Jung, Mae-Myeong (College of Veterinary Medicine, Chonbuk National University)
Choi, Min-Jun (College of Veterinary Medicine, Chonbuk National University)
Lee, Sung-Il (Toyama Medical and Pharmaceutical University)
Lee, Hee-Kwon (Korean Raspberry Experiment Station, Gochanggun Agriculture Development & Technology Center)
Jeon, Byung-Hun (College of Oriental Medicine, Wonkwang University)
Baek, Byeong-Kirl (College of Veterinary Medicine, Chonbuk National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.2, 2005 , pp. 375-379 More about this Journal
Abstract
This study was conducted to investigate the effects of black raspberry wine, administered per os on testosterone levels in rabbits. Black raspberry wine containing 13% alcohol(v/v) was prepared from ripe fruits of Rubus coreanus fermented with Saccharomyces cervisiae. Experimental rats were divided into 2 groups(A and B) with 2 animals group: Group A received black raspberry wine. Group B received 13% concentrated alcohol('Soju') over a period of 6 weeks. all animals were monitored weekly for testosterone levels by radioimmunoassay using $^{125}I$ labeled anti-testosterone monospecific antibody. There was a significant(1.7-2.33 fold) increase in testosterone levels in Group A with a peak at 1 week post administration of black raspberry wine. There was no significant change in testosterone levels of rabbits in Group B. These data point to yet uncharacterized phytotestronegenic mechanisms of black raspberry wine that appear to be independent of ethyl alcohol. Further investigation of the mechanism of action of this fruit is warranted. These observations have potential implications for human reproductive health.
Keywords
Rubus coreanus; rabbit; testosterone; black raspberry wine;
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