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Effects of methanol extract of Cyperus rotundus on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans  

Yu, Hyeon-Hee (Department of Food and Nutrition, Kunsan National University)
Seo, Se-Jeong (Department of Oral Biochemistry, School of Dentistry, Wonkwang University)
Kim, Yeon-Hwa (Department of Oral Biochemistry, School of Dentistry, Wonkwang University)
Lee, Hae-Youn (Department of Oral Biochemistry, School of Dentistry, Wonkwang University)
Lee, Yong-Wuk (Department of Oral Biochemistry, School of Dentistry, Wonkwang University)
Jeon, Byung-Hun (Department of Oriental Pathology, College of Oriental Medicine, Wonkwang University)
You, Yong-Ouk (Department of Oral Biochemistry, School of Dentistry, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.2, 2005 , pp. 370-374 More about this Journal
Abstract
Streptococcus mutans (S. mutans) is known as the causative bacterial playing the most important role informing plaque and it is being noticed as major causative bacteria of dental caries. Therefore, development of more effective, substantial and safe preventive agent against dental caries and periodontal disease is honestly required. The present study was designed to investigate the effect of Cyperus rotundus (Cyperaceae) methanol extracts on the growth, acid production, adhesion, and insoluble glucan synthesis of S. mutans. The methanol extract of C. rotundus showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition at the concentration of 0.5, 1, 2 and 4 mg/ml compared to the control group. The extracts markedly inhibited S. mutans adherence to HA treated with saliva, and cell adherence was repressed by more than 50% at the concentration of 0.5 mg/ml and complete inhibition was observed at the concentration of 4 mg/ml. On the activity of glucosyltransferase which synthesizes water insoluble glucan from sucrose, methanol extract of C. rotundus showed more than 10% inhibition over the concentration of 2 mg/ml. Thus, the application of C. rotundus can be considered a useful and a practical method for the prevention of dental caries.
Keywords
Cyperus rotundus; dental caries; Streptococcus mutans;
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