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Inhibitory Effect of Saururus chinensis (Lour.) Baill Extracts on Allergy in Mouse Models  

Suk, Min-Hee (Department of Physiology.Biomedical Research Center of Oriental Medicine, Dong-Eui University)
Kang, Kyung-Hwa (Department of Physiology.Biomedical Research Center of Oriental Medicine, Dong-Eui University)
Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University)
Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dong-Eui University)
Lee, Yong-Tae (Department of Physiology.Biomedical Research Center of Oriental Medicine, Dong-Eui University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.1, 2005 , pp. 146-151 More about this Journal
Abstract
We investigated the effect of Saururus chinensis (Lour.) Baill (SCB) on allergy in mice. We conformed compound 48/80-induced mesenteric mast cell degranulation, active systemic anaphylatic shock and histamine release. Also observed acetic acid-induced vascular permeability and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis. SCB inhibited mesenteric mast cell degranulation and active systemic anaphylatic shock induced by compound 48/80 dose-dependently. When SCB was pretreated by intra-peritoneal injection, the plasma histamine levels were reduced. SCB also significantly inhibited acetic acid-induced vascular permeability and anti-DNP IgE-mediated passive cutaneous anaphylaxis. In addition, SCB reduced IL-10 mRNA expression of the lung on ovalbumin-induced allergy. These results indicate that SCB inhibits allergy.
Keywords
Saururus chinensis (Lour.) Baill; Allergy; compound 48/80; cytokine; histamine;
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Times Cited By KSCI : 3  (Citation Analysis)
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