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Isolation of Angiotensin Converting Enzyme Inhibitory Component from the Seeds of Xanthium strumarium  

Lee, Yun-Mi (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI), Wonkwang University)
Kim, Myung-Gyu (Professional Graduate School of Oriental Medicine, Wonkwang University)
Jang, Ji-Yeon (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI), Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.1, 2005 , pp. 119-123 More about this Journal
Abstract
In the courses of in vitro screening for the angiotensin converting enzyme (ACE) inhibitory activity of the various extracts from medicinal plants, n-BuOH soluble extract of the seeds of Xanthium strumarium was found to exhibit distinctive angiotensin converting enzyme (ACE) inhibitory activity. Bioassay-guided fractionation and purification of the n-BuOH soluble extract of the seeds of Xanthium strumarium afforded a new $xanthiazone-11-{\beta}-glucopyranoside$. The ACE activity was significantly inhibited by the addition of a new $xanthiazone-11-{\beta}-glucopyranosidein$ a dose-dependent manner of which $IC_{50}$ value was $21.8\;{\mu}g/ml$.
Keywords
angiotensin converting enzyme (ACE); Xanthium strumarium; xanthiazone-11-$\beta$-glucopyranosidein;
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