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Antimalarial Activity and Cytotoxicity of Herb-medicine Against P. falciparum in vitro  

Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
Kim, Jong-Ho (Department of Infection Biology, College of Medicine, Wonkwang University)
Park, Hyun (Department of Infection Biology, College of Medicine, Wonkwang University)
Kim, Yong-Man (Department of Infection Biology, College of Medicine, Wonkwang University)
Kim, Min-Kyeoung (Department of Infection Biology, College of Medicine, Wonkwang University)
Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Kim, Hye-Sook (Faculty of Pharmaceutical Siences, Okayama University)
Yun, Ki-Jung (Department of Pathology, College of Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.1, 2005 , pp. 102-105 More about this Journal
Abstract
Eighteen methanol extracts of herb-medicine used for malarial and antipyretic therapies in Korea were assessed for their antimalarial activities. Eighteen extracts showed evident antimalarial activity with $EC_50$ values ranged from $2.8\;to\;110mg/m{\ell}$. Evodia fructus showed the antimalarial activity of $EC_50\;=\;4.1\;mg/m{\ell}$ and higher selective toxicity(>8) with no cytotocixity for mammalian cells. This indicated that Evodia fructus is potent for a new effective and safe antimalarial agent. The methanol extract of Physalli radix had also strongest antiplasmodial activity with $EC_50$ value of $2.8{\mu}g/m{\ell}$.
Keywords
Plasmodium falciparum; traditional medicine; antimalarial drug; drug-resistant malaria; Evodia fructus; Physalli radix;
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  • Reference
1 Winstanley PA. Chemotherapy for falciparum malaria: the armoury, the problems and prospects. Parasitol Today 16: 146-153, 2000.   DOI   ScienceOn
2 Kim, H.-S., Shibata, Y., Wataya, Y., Tsuchiya, K., Masuyama, A. and Nojima, M. Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7-pentoxocanes and 1,2,4,5tetroxanes. J. Med. Chem., 42(14), 2604-2609, 1999.
3 Yoshioka, A.; Tanaka, S.; Hiraoka, O.; Koyama, Y.; Hirota, Y.; Ayusawa, D.; Seno,T.; Garrett, C.,; Wataya, Y. Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J. Biol. Chem. 262, 8235-8241, 1987.
4 Hur J. 'Dong-yi-bo-gam', 613-623, China Traditional Chines Medicine Press, 1st ed., beijing, China, 1995.
5 Ridley, RG. Medical need scientific opportunity and the drive for antimalarial drugs. Nature 415, 686-693, 2002.
6 許浚 : 東醫寶鑑, 서울, 대성문화사. 1992.
7 World Health Organization: The World Health Report 2001. Mental health: New understanding, new hope. World Health Organization, Geneva, 2001.
8 Trager, W.; Jensen, J. B. Human malaria parasites in continuous culture. Science 193, 673-675, 1976.
9 Kim, H-S.; Miyake, H.; Arai, M.; Wataya, Y.; A potent antimalaria activity of 5-fluoroorotate in combination with sulfamonomethoxine against Plasmodium falciparum in vitro and Plasmodium berghei in mice. Parasitoi. Int 47,59-67, 1998.
10 [중약대사전] , 3270, 상해과학출판사, 일본 소학사 편,1986.