Browse > Article

Bone Mineral Density of Normal Korean Adult Using QCT  

Lee Jong Deok (Department of Diagnostic Radiology, College of Oriental Medicine, Wonkwang University Gwangju Wonkwang hospital, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1918-1926 More about this Journal
Abstract
Osteoporosis is defined as a progressive systemic skeletal disorder characterized by low bone mineral density, microarchitectual deteriorations of bone and susceptibility to fracture. numerous methods have been used for quantitative assessment of the skeleton in osteoporosis. QCT has been shown to measure changes in trabecular mineral content in the spine with great sensitivity and precision. To provide the normal reference values and changes of lumbar spinal bone mineral density in korean adult spinal bone mineral density was evaluated in 451 women (229 premenopausal and 222 postmenopausal women) and 206 men, aged 20 to 74 years old in Wonkwang hospital from 2000 to 2004, which was carried out by using QCT. women with oophorectomy, vertebral compression fracture, any history of endocrine disease and use of drugs that alter bone metabolism were excluded. According to the WHO definition, a patient is osteoporotic based on a bone mineral density(BMD) measurement that is 2.5 standard deviations (SDs) below typical peak bone mass of young healthy white women. This measurement of standard deviation from peak mass is called the T score. BMD values of normal women in their 20-24 years, 25-29 years, 30-34 years, 35-39 years, 40-44 years, 45-49 years, 50-54 years, 55-59 years, 60-64 years, 65-69 years, over 70 years were 168.95㎎/㏄ K₂PHO₄, 155.41㎎/㏄ K₂PHO₄, 166.87㎎/㏄ K₂PHO₄, 160.67㎎/㏄ K₂PHO₄, 154.06㎎/㏄ K₂PHO₄, 132.04㎎/㏄ K₂PHO₄, 114.05㎎/㏄ K₂PHO₄, 91.78㎎/㏄ K₂PHO₄, 78.61 ㎎/㏄ K₂PHO₄, 61.35㎎/㏄ K₂PHO₄, 50.53㎎/㏄ K₂PHO₄ Mean bone density of normal women was 115.77K₂PHO₄ K₂PHO₄. BMD values of normal men in their 20-24 years, 25-29 years, 30-34 years, 35-39 years, 40-44 years, 45-49 years, 50-54 years, 55-59 years, 60-64 years, 65-69 years, over 70 years were 171.46㎎/㏄ K₂PHO₄, 162.19㎎/㏄ K₂PHO₄, 155.62㎎/㏄ K₂PHO₄, 147.28㎎/㏄ K₂PHO₄, 137.56㎎/㏄ K₂PHO₄, 137.56㎎/㏄ K₂PHO₄, 101.25㎎/㏄ K₂PHO₄, 109.00㎎/㏄ K₂PHO₄, 103.32㎎/㏄ K₂PHO₄, 91.53㎎/㏄ K₂PHO₄, 88.35㎎/㏄ K₂PHO₄ Mean density of normal men was 115.77㎎/㏄ K₂PHO₄. Peak bone density of women and men was in the age group of 20-24 years and 168.95㎎/㏄ K₂PHO₄, 171.46㎎/㏄ K₂PHO₄, respectively. Bone loss was increased with aging and was accelerated in postmenopausal women than that of premenopausal women. The total loss of BMD for women and men was 70.09% and 48.47%, respectively. Postmenopausal women(mean BMD : 85.83㎎/㏄ K₂PHO₄) had significantly lower BMD than premenopausal women(meand BMD : 144.80㎎/㏄ K₂PHO₄)(p<0.001). The annual loss of BMD of women and men was 2.702㎎/㏄ K₂PHO₄ and 1.795㎎/㏄ K₂PHO₄, respectively. This study provided the BMD reference data for normal korean adult. further studies on BMD in healthy adult and comparison with published data are needed.
Keywords
osteoporosis; bone mineral density; QCT;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Current and innovative methods for noninvasive bone densitometry /
[ Sartoris DJ.;Resnick D. ] / Radiol Clin N Am
2 Osteoporosis : Assessment by quantitative tomography /
[ Genant HK;Ettinger B;Cann CE ] / Orthop Clin North America
3 Measurement of lumbar spine bone mineral : a comparison of dual photon absorptiometry and computed tomography /
[ Sambrook, PN;Bartlett C;Evans R;Hesp R;Kartz D;Reeve J ] / British J Radio   ScienceOn
4 Quantitative computed tomography for spinal mineral assessement : Current status /
[ Genant HK;Cann CE;Etting B(et al) ] / J Comput Assist Tomogr
5 Assesment of metabolic bone disease by quantitative computed tomography /
[ Richadson ML;Genant HK;Cann CE(et al) ] / Clin Ortho Rel Res
6 Quantitative CT for determination of bone mineral density : A review /
[ Cann CE. ] / Radiology
7 Age-related changes in cortical and cancellous vertebral bone density in girls : Assessment with Quantitative CT /
[ Mora S;Goodman WG;Loro ML;Roe TF;Sayre J;Gilsanz V. ] / AJR   ScienceOn
8 Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation /
[ Ray NF;Chan JK;Thamer M;Melton III LJ. ] / J Bone Miner Res   ScienceOn
9 Hip fractures : a worldwide problem today and tomorrow /
[ Melton III LJ. ] / Bone
10 Postmenopausal osteoporosis /
[ Stevenson JC;Whitehead MI. ] / Br Med J
11 Epidemiology of vertebral fracture in women /
[ Melton LJ III;Kan SH;Frye MA(et al) ] / Am J Epidemiol
12 Vertebral fractures and mortality in older women : study of Osteoporosis Fractures Research Group /
[ Kado DM;Browner WS;Palermo L(et al) ] / Arch Intern Med   ScienceOn
13 Vertebral fracture and other predictors of physical impairment and health care utilization /
[ Huang C;Ross PD. ] / Arch Intern Med   ScienceOn
14 Precision and accuracy of bone mineral determination by the direct photon absorptiometric method /
[ Cameron JR;Mazess RB;Sorenson JA. ] / Invest Radiol
15 /
[ Markhard L;Lindsay R;Dempster DW(et al) ] / Proceedings Clinical disorders of bone and mineral metabolism
16 Total bone mineral and lean body mass by dual photon absorptiometry. I. theory and measurement procedure /
[ Pepper WW;Maxess RB. ] / Calcif Tissue Int   ScienceOn
17 Evidense for two distinct syndromes of involuational osteoporosis /
[ Riggs BL;Melton LJ III. ] / Am J Med
18 Involutional osteoporosis /
[ Riggs BL;Melton LJ III. ] / N Eng J Med   ScienceOn
19 /
[ National Osteoporosis Foundation ] / American's bone health : the state of osteoporosis and low bone mass in our nation
20 Osteoporosis : Diagnosis with lateral and posteroanterior dual X-ray absorptiometry compared with quantitative CT /
[ Guglielima G;Grimston SK;Fischer KC;Pacifici R. ] / Radiology
21 On aging bone loss /
[ Mazess RB. ] / Clinic Ortho
22 Clinical, biochemical, radiological, epidemiologic and economic features of osteoporosis /
[ Johnston CC;Epstein S. ] / Orthop Clin North Am
23 Bone dynamics : stress, strain and fracture /
[ Martin AD;McCulloch RG. ] / J Sports Sci
24 Epidemiology and outcomes of osteoporotic fracture /
[ Cummings SR;Melton LJ. ] / Lancet
25 Source of estrogen production in postmenopausal women /
[ Grodin JM;Siiteri PK;Mcdonald PC. ] / J Clin endoclinol Metab
26 Risk for osteoporosis in black women /
[ Aloia JF;Vaswani A;Yeh JK;Flaster E. ] / Calcif Tissue Int
27 Low risk of vertebral fracture in Mexical Americal women /
[ Bauer RL;Deyo RA. ] / Arch intern Med   ScienceOn
28 Lifetime risks of hip, Colles' or vertebral fracture and coronary heart disease among with postmenopausal women /
[ Cummings SR;Black DN;Rubin SM(et al) ] / Arch Intern Med   ScienceOn
29 Quantum concept of bone remodeling and turnover : Implication for the pathogenesis of osteoporosis /
[ Parafitt AM. ] / J Clin Invest
30 Report of the Task Group on Reference Man /
[ Snyder W. ] / International Congress of Radiation Protection
31 CT scanning for measurement of bone mineral in human spine /
[ Marshall A;Weissberger RG;Zanenhold SA(et al) ] / J Comput Assist Tomogr   ScienceOn
32 Changes in trabecular pattern of the upper end of the femur as index of osteoporosis /
[ Singh M;Nagrath AR;Maini PS. ] / J Bone Joint Surg
33 Determination of osteoporosis in patient with fractured femoral neck using the singh index A Jerusalem Study /
[ Pogrund H;Rigal WM;Makin MR. ] / Clin Orthop
34 Measurement of bone mineral in vivo ; An improved Method /
[ Cameron JR;Sorrenson J. ] / Science
35 Quantitative CT assessment of the lumbar spine and radius in patient with osteoporosis /
[ Grampp S;Jergas M;Lang P(et al) ] / AJR   ScienceOn
36 Vertebral fractures and mortality in older women : a prospective study. Study of Osteoporotic Fractures Research Group /
[ Kado DM;Browner WS;Palermo L. ] / Arch Intern Med   ScienceOn
37 Population-based study of survival after osteoporotic fractures /
[ Cooper C;Atkinson EJ;Jacobsen SJ. ] / Am J Epidemiol
38 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis : synopsis of a WHO report. WHO Study Group /
[ Kans JA. ] / Osteoporosis Int   ScienceOn
39 Spine and femur density using dual-photon absorptiometry in US white women /
[ Mazess RB;Barden HS;Ettinger M;Johnston C;Dawson-Hughes B;Baran D;Powel M;Notelovitz M. ] / Bone and Mineral
40 Bone densitometry and clinical decision making in osteoporosis /
[ Riggs BL;Wahner HW. ] / Ann Int Med
41 Dual energy radiography : a preliminary comparative study /
[ Pacifici R;Rupich R;Vered I(et al) ] / Calig Tissue Int   ScienceOn
42 Quantitative computed tomography for prediction of vertebral fracture risk /
[ Cann CE;Genant HK;Kolb FO(et al) ] / Metab Bone Dis Relat Res
43 Critical years and stages of puberty of spinal and femoral bone mass accumulation during adolescence /
[ Bonjour J-P;Theintz G;Buchs B;Slosman D;Rizzoli R. ] / J Clin Endocrinol Metab
44 Differential changes in bone mineral density of the appendicular and axial skeleton with aging /
[ Riggs BL;Wahner HW;Dunn WL(et al) ] / J Clin Invest   ScienceOn
45 Performance evaluation of a dual-energy X-ray bone densitometer /
[ Mazess R;Colik B;Trempe J;Barden H;Hanson J. ] / Calig Tissue Int
46 Computed tomography for the measurement of bone mineral in the human spine /
[ Weissberger MA;Zamenhof RG;Aronow S(et al) ] / J Comput Assist Tomogr   ScienceOn
47 Quantification of trabecular bone with low-dose computed tomography /
[ Ruegsegger R;Anliker M;Dambacker M. ] / J Comput Assist Tomogr   ScienceOn
48 Quantification of bone mineralization using computed tomography /
[ Ruegsegger P;Elsasser U;Anliker M(et al) ] / Radiology
49 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures /
[ Marshall D;Johnell O;Wedel H(et al) ] / BMJ   ScienceOn
50 A reliable in vivo measurement of bone-mineral content /
[ Sorenson JA;Cameron JR. ] / J bone and Joint Surg
51 A quantitative approach to simple radiographic diagnosis of osteoporosis : its application to the osteoporosis of rheumatoid arthritis /
[ Saville PD;Kharmosh O. ] / Arthritis Rheum
52 Recognition of osteoporosis by primary care physicians /
[ Gehlbach SH;Fournier M;bigelow C(et al) ] / Am J public Health