[KSCI] Korea Science Citation Index Service

Effects of Mix-1 on Anti-CD40 Antibody and Recombinant IL4- Induced Cytokine Production and Immunoglobulin E in Highly Purified Mouse B Cells

Kim Jung Hwan (Department of Pathology, College of Oriental Medicine, Daejeon University)
Choi Sun Mi (Korea Institute of Oriental Medicine, College of Oriental Medicine, Daejeon University)
Lee Yong Gu (Department of internal medicine, College of Oriental Medicine, Daejeon University)
Namgoong Uk (Korea Institute of Oriental Medicine, College of Oriental Medicine, Daejeon University)
Kim Dong Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1869-1880 More about this Journal

Abstract

In the oriental medicine, a mixture of herbs has been commonly used as important components to control allergic and inflammatory diseases. In the present study, we prepared a mixture of Dictamni Radicis Cortex(Baiksunpee), Houttuyniae Herba(Uhsungcho), and Aurantii Immaturus Fructus(Jisil) to examine its anti-allergic effects in activated mouse splenic cells and found that Mix-1 is involved in regulating levels of B cell activating factors (CD23 and CD11a), IL-1β, IL-6, IL-10, TNF-α, and 1gE as well as HRF expression. It was observed that Mix-1 did not have cytotoxic effects on mLFC. Mix-1 showed inhibition of CD23 and CD11 alpaha expression in mouse B cells, and also decreased the production of IL-6, TNF-α, and 1gE. Both RT-PCR and ELISA analyses indicated that IL-6 and TNF alpha production were regulated at the gene expression level. In contrast, IL-10 mRNA and protein levels were increased in activated B cells by Mix-1 treatment. We also found that Mix-1 inhibited B cell proliferation and inhibited histamine releasing factor(HRF) expression, suggesting its inhibitory effect on histamine secretion. These data indicated that Mix-1 has an anti-allergic effect in activated macrophages and further suggest the possible application of Mix-1 as a therapeutic agent for the treatment of allergy-related diseases.

Keywords

Anti-allergic; RT-PCR; ELISA; B cells; cytokine; CD23+; CD11α+; 1gE; HRF;

Citations & Related Records

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