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Effect of Kangdangboeumbang on the Anti-diabetic Activity in NOD Mice  

Song Ho Cheol (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1628-1634 More about this Journal
Abstract
This study was aimed to verify the anti-diabetic activity of Kangdangboeumbang(KBB) in NOD mice which is Insulin Dependent Diabetes Mellitus(IDDM). The reduction of blood glucose after oral administration between 14 weeks by 2 weeks period to a NOD mice in KBB extract treatment group was showed from 7 day after comparing with control group. KBB extract treatment group increasd insulin secretion amount of serum than control group and decreased IFN­γ production. The pancreatic β-cells is destroyed by Th1-dependent autoimmune disease in NOD mice. KBB extract treatment group intercepted the progress of edematous islet controlling inflammatory mononuclear cells of infiltration that also destruction of pancreatic β-cells electively in a NOD mice.
Keywords
NOD(nonobese diabetic) mice; Kangdangboeumbang(降糖補陰方); IDDM;
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Times Cited By KSCI : 3  (Citation Analysis)
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