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Angiogenic Inhibitory Effect of Zingiberis Rhizoma  

Nam Sang Choon (Department of Oriental Medicine, Kyunghee University)
Myung Eu gene (Department of Oriental Medicine, Kyunghee University)
Kang Hee (Department of Oriental Medicine, Kyunghee University)
Shim Bum Sang (Department of Oriental Medicine, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Kyunghee University)
Choi Seung Hoon (Department of Oriental Medicine, Kyunghee University)
Ahn Kyoo Seok (Department of Oriental Medicine, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1608-1612 More about this Journal
Abstract
This study was conducted to investigate angiogenic inhibitory effect of Zingiberis Rhizoma methanol extract using ECV-304 cells and HT1080 fibrosarcoma cells. The viability of ECV-304 was 30% at 50㎍/㎖ of Zingiberis extract and that of HT1080 was 30% at 100㎍/㎖. Using the BrdU incorporation assay, Zingiberis inhibited the DNA synthesis of ECV-304 and HT1080 by 70% and 50% at 200㎍/㎖. In tube formation assay, at 10㎍/㎖ of Zingiberis, tube network began to degrade and at higher doses, it was completely destroyed. Zymography demonstrated that Zingiberis extract decreased MMP-9 at 10㎍/㎖ and higher doses remarkably inhibited the expression of MMP-9. These data indicate that Zingiberis Rhizoma has angiogenic inhibitory effects and shows the possibility of future anti-metastatic drug.
Keywords
Zingiberis Rhizoma; angiogenesis; ECV304; HT1080;
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