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Mechanism Study of Cheonmabanhwa-Tang on the Cerebral Ischemia in Rats - Focusing arround Improvement in Changes of Cerebral Hemodynamics -  

Yang Gi Ho (College of Oriental Medicine, Dongshin University)
Lee Geum Soo (College of Oriental Medicine, Dongshin University)
Kim Young Kun (College of Oriental Medicine, Dongshin University)
Jeong Hyun Woo (College of Oriental Medicine, Dongshin University)
Kim Gye Yeop (College of Oriental Medicine, Dongshin University)
Jeon Byung Gwan (Department of Environmental Engineering, Dongshin University)
Lee Won Suk (Department of Phamachology, College of Medicine, Busan University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1404-1409 More about this Journal
Abstract
Cheonmabanhwa-Tang(CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam. This Study was designed to investigate the mechanism of Prescription on cerebral hemodynamics [regional cerebral blood flow(rCBF) and pial arterial diameter(PAD)J in cerebral ischemia rats, The results in cerebral ischemic rats were as follows: Both rCBF and PAD were significantly and stably increased by CBT (10 ㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. Pretreatment with indomethacin(1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase significantly but unstably increased the CBT-induced increases in PAD as well as rCBF during the period of cerebral reperfusion. Pretreatment with methylene blue(10 (.1.㎍/㎏, i.p.), an inhibitor of guanylate cyclase significantly but unstably increased the CBT-induced increases in PAD as well as rCBF during 150 minutes of cerebral reperfusion, but decreased stably the CBT-induced increases in rCBF and PAD after 180 minutes of cerebral reperfusion. In conclusion, the present authors thought that CBT caused effect on cerebral hemodynamics via mediation of cyclooxygenase.
Keywords
Cheonmabanhwa-Tang; regional cerebral blood flow; pial arterial diameter; cerebral ischemia; cyclooxygenase; methylene blue;
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