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Effect of Kamichungbieum on Immune Reaction  

Eun Jae Soon (College of Pharmacy, Woosuk University)
Lee Dong Hee (College of Pharmacy, Woosuk University)
Jeon Yong Keun (College of Pharmacy, Woosuk University)
Kwon Young An (College of Science and Engeeniring, Woosuk University)
Kwon Jin (Department of Medical Administration)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1391-1396 More about this Journal
Abstract
The purpose of this research was to investigate the effects of supercritical fluid extract of Kamichungbieum (SFE) on immune reaction. SFE did not affect the subpopulation of murine splenocytes and increased the production of interleukin-2 in serum. Also, SFE inhibited the influx of Ca/sup 2+/ into mast cells and the release of histamine from mast cells. Furthermore, SFE decreased the phagocytic activity of murine macrophages, These results indicate that SFE may be useful for the treatment of allergy related disease via inhibition of histamine release from mast cells and decrease of phagocytic activity of murine macrophages.
Keywords
Kamichungbieum(加味淸鼻飮); supercritical fluid extract; cytokine; phagocytosis; mast cell; histamine, Ca/sup 2+/;
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