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Study on the Anti-angiogenic Activity of KMKKTE  

Lee Hyo Jeong (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Lee Eun Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Oh Se Soon (Department of Oriental Pathology, Kyunghee University)
Ahn Kyoo Seok (Department of Oriental Pathology, Kyunghee University)
Park Young Doo (Graduate School of Biotechnology, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.4, 2004 , pp. 990-994 More about this Journal
Abstract
Cancer is an intractable disease for humans to overcome. Recently natural products or Oriental prescriptions have been on the spotlight to develop anticancer agents with little side-effects and good efficacy. KamikeKyuktang has been used for the treatment of cancer in Oriental medicine. However, its anti-cancer mechanism still remains unclear. KMKKTE is an ethanol extract of KamikeKyuktang composed of 12 medicinal herbs. Anti-proliferative effects of KMKKT was investigated on Lewis lung carcinoma cell (LLC) and A549 (human lung cancer cells). Half-maximal inhibition of the LLC and A549 cell proliferation by KMKKTE was found approximately 125㎍/㎖ and 250㎍/㎖, respectively. It also effectively inhibited the proliferation of HUVEC cells treated by bFGF and VEGF up to 30% of control at 125㎍/㎖ and the cell migration to 80% at 25 ㎍/㎖ in concentration dependent manner. Tube formation of HUVEC cells on matrigel also was significantly suppressed from 25㎍/㎖ of KMKKTE. Taken together, these results demonstrate that KMKKTE has antiangiogenic activity and be applied to angiogenesis dependent cancers.
Keywords
KMKKTE; LLC; A549; proliferation; tube formation;
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  • Reference
1 Endostatin: an endogenous inhibitor of angiogenesis and tumor growth /
[ O'Reilly MS;Boehm T;Shing Y;Fukai N;Vasios G;Lane WS(et al.) ] / Cell
2 /
[ 대한병리학회 ] / 병리학
3 SV40-transformed human lung fibroblasts secrete a 92-kDa type Ⅳ collagenase which is identical to that secreted by normal human macrohpages /
[ Wilhelm SM;Collier IE;Marmer BL;Eisen AZ;Grant GA;Goldberg GI. ] / J Biol Chem
4 Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma /
[ O'Reilly MS;Holmgren L;Shing Y;Chen C;Rosenthal RA;Moses M(et al.) ] / Cell
5 Anti-metastastic effects of Xuefuzhuyutang /
[ Lee JH;Shim BS;Ahn KS;Choi SH. ] / Journal of Korean Oriental Oncology
6 Study on the Angiogenic Inhibition Effects of Molyaksan /
[ Kang DI;Kim SH;Shim BS;Choi SH;Ahn KS. ] / Korean Journal of Oriental Medical Pathology
7 Effects of Huoluoxiaolindan on Anti-metastasis /
[ Sohn JG;Kim SH;Seok DS;Shim BS;Choi SH;Ahn KS. ] / Korean Journal of Oriental Medical Pathology
8 Anti-angiogenic effects of Sipjeondaebo-tang /
[ Choi H;Park JH;Yu YB;Shim BS;Choi SH;Ahn KS. ] / Korean Journal of Oriental Physiology & Pathology
9 Angiogenic inhibition effects of several herbs supplementing Qi and blood /
[ Lee JW;Kim HY;Kang H;Yu YB;Shim BS;Choi SH;Ahn KS. ] / Korean Journal of Oriental Physiology & Pathology
10 Inhibition by galloyglucose(GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells /
[ Ata, N;Oku, T;Hattori, M;Fujii, H;Nakajima, M;Saiki, I. ] / Oncology Research
11 Rapid colormetric assay for celluar growth and survival : application to proliferation and cytotoxicity assay /
[ Mosmann T. ] / J immonol Method
12 Evalution of a soluble tetrazolium/ formazan assay for cell growth and drug sensivity in culture using human and other tumor cell lines /
[ Scudiero, D.A.;Shoemaker, RH;Pall, KD ] / Cancer Res.
13 Angiostatin: a novel angiogenesis inhibitor that mediate the suppression of metastasis by a Lewis lung carcinoma cell /
[ O' Reilly, M. S.;Holmgren, L.;Chen C.;Rosental, R. A.;Moses, M.;Lane,W.S; Cao, Y.;Sage, E., H.;Folkman, J. ] /
14 Angiogenesis mediated by soluble forms E-selctin and vascular cell adhesion molecule-1 /
[ Koch, A. E.;Halloran, M. M.;Haskell, C. J.;Shah, M R.;Polverini, P. J ] / Nature
15 Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo /
[ Grant, D.S.;Kinsella, J. L.;Fridman, R.;Auerbach, B.;Piasecki, A.;Yamada, Y.; zain, M.;nad Kleinman, H. K. ] / J. cell physiol.
16 Platelet activation, coagulation and angiogenesis in breast and prostate carcinoma /
[ Caine GJ;Lip GY;Stonelake PS;Ryan P;Blann AD. ] / Thromb Haemost
17 Antiangiogenic activity of aplidine, a new agent of marine origin /
[ Taraboletti G;Poli M;Dossi R;Manenti L;Borsotti P;Faircloth GT;Broggini M; D'Incalci M;Ribatti D;Giavazzi R. ] / Br J Cancer.
18 CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo /
[ Trikha M;Zhou Z;Nemeth JA;Chen Q;Sharp C;Emmell E;Giles-Komar J; Nakada MT. ] / Int J Cancer.   ScienceOn
19 Inhibition of angiogenesis by salmosin expressed in vitro /
[ Kim SI;Kim KS;Kim HS;Choi MM;Kim DS;Chung KH;Park YS. ] / Oncol Res
20 Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana /
[ Kim Y;Kim SB;You YJ;Ahn BZ. ] / Planta Med.   ScienceOn