Browse > Article

The Effects of Anti-Alzheimer on CT105-induced PC 12 Cells by Corynoxeine Isolated from Uncariae Ramulus et Uncus  

Kang Hyung Won (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
Kim Sang Tae (JuAm of Research Institute Bioscience & Biotechnology)
Lyu Yeoung Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.4, 2004 , pp. 1111-1119 More about this Journal
Abstract
In this study, we investigated that the effects of corynoxeine on the apoptosis by inducible CT105 in PC 12 cells and neuronpathogenic agent as CT105 confirmed with apoptosis, DNA fragmentation, neurite outgrowth and immunocytochemistry analysis This study examines whether corynoxeine have an anti-alzhmeimer agent by inhibition of apoptosis by CT105 and induces neurite outgrowth. Cytotoxicity was assessed in PC12 cell cultures by DNA fragmentation and measuring lactate dehydrogenase (LDH) in the culture media. The treatment of corynoxeine in exposure of cultures to CT105 and provided complete protection against cytotoxicity. CT105-induced cytotoxicity was blocked by apoptotsis, repaired by DNA fragmentation, neurite outgrowth and exposure to CT105 expression and regenerated with neurite outgrowth and immunocytochemistry by corynoxeine. These results indicate that in neuronal cell cultures, damage of T105, repaired excitotoxicity by corynoxeine and CT105-induced cytotoxicity is blocked primarily by the activation of anti-apoptosis.
Keywords
corynoxeine; Uncariae ramulus et uncus; cytotoxicity; apoptosis; CT105; APP; Alzheimer disease;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormailties /
[ Tabaton M;Cammarata S;Mandybur T;Richy P;Kawai M;Perry G;Gambetti P ] / Brain Res
2 /
[ 李符永(譯) ] / ICD-10 정신 및 행동장애 분류
3 /
[ 김지혁;황의완 ] / 동의정신의학
4 Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer`s disease brain /
[ Reznik-Wolf H;Machado J;Haroutuian V;DeMacro L;Walter GF;Goldman B; Davidson M;Johnston JA;Lannfelt L;Dani SU;Friedman E ] / J Neurogenet
5 Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein; identification of hidden and cleaved tau epitopes and a new phosphorylation site /
[ Dickson DW;Ksiezak-Reding H;Liu WK Davies P;Crowe A;Yen SH ] / Acta Neuropathol (Berl)
6 Suppression of an amyliod beta peptide-mediated calcium chnnel response by a secreted beta-amyloid precursor protein /
[ Li WY;Butler JP;Hale JE;McClure DB;Little SP;Czilli DL;Simmons LK ] / Neuroscience
7 Neurotrophic and neurotoxic effects of amyloid beta protein, Reversal by tachykinin neuropeptides /
[ Yankner BA;Duffy LK;Kirschner DA ] / Science   ScienceOn
8 Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells /
[ Fukuchi K;Kunkel DD;Schwartzkroin PA;Kamino K;Ogburn CE;Furlong CE;Martin GM ] / Exp Neurol
9 Neurotoxicity of a caroboxy terminal fragment of the Alzheimer's amyloid precursor protein /
[ Kim SH;Suh YH ] / J. Neurochem
10 Enhanced release of secreted form of Alzheimer's amyloid precursor protein(<TEX>${\beta}$</TEX>APP) in PC12 cells by nicotine /
[ Kim SH;Kim YK;Jeong SJ;Haass C;Kim YH;Suh YH ] / Molecular Pharmacology
11 Membrane currents induced in Xenopus oocytes by the carboxyl terminal fragment of the amyloid precursor protein /
[ Fraser S;Suh YH;Chong YH;Djamgoz MA ] / J. Neurochem
12 Molecular physiology, biochemistry and pharmacology of Alzheimer's amyloid precursor protein(APP) /
[ Suh YH;Chong YH;Kim SH;Choi w;Kim KS;Jeong SJ(et al.) ] / Annals of NY Acad Sci
13 Effects of fragments of β-amyloid precursor protein on parallel fiber-purkinje cell synaptic transmission in rat cerebellum /
[ Hartell NA;Suh YH ] / J. Neurochemistry
14 左歸飮과 右歸飮에 의한 活性 酸素類의 消去작용과 抗酸化 酸素系의 活性 增加 효과에 대한 硏究 /
[ 鄭智天 ] / 大韓韓醫學會誌
15 麝香蘇合元이 Alzheimer's disease 모델 白鼠의 학습과 기억에 미치는 영향 /
[ 황의완 ] / 동의신경정신과학회지
16 세심탕에 의한 뇌성상세포로부터 염증성세포활성물질의 분비 억제효과 /
[ 김태헌;김준한;강형원;유영수 ] / 동의신경정신과학회지
17 생체외 알츠하이머병 실험모델에서 星香正氣散加蒲公英의 효과에 관한 연구 /
[ 박진성;강형원;유영수 ] / 동의신경정신과학회지
18 益精地黃湯이 치매병태모델에 미치는 영향 /
[ 최병만;이상룡 ] / 동의신경정신과학회지
19 /
[ 辛民敎 ] / 原色臨床本草學
20 導痰益氣活血湯이 Alzheimer`s disease 병태 모델의 생화학적 변화 및 행동에 미치는 영향 /
[ 정인철 ] / 대전대학교 대학원(박사)
21 Familial Alzheimer's disease cells abnormal abnormally accumulate beta-amyloid harbouring peptides preferentially in cytosol but not in extracelluar fluid /
[ Matsmoto A;Matsumoto R ] / Eur J Biochem
22 Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein /
[ Nalbantoglu J;Tirado-Santiago G;Lahsaini A;Poirier J;Goncalves O;Verge G(et al.) ] / Nature
23 A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor /
[ Lu DC;Rabizadeh S;Chandra S;Shayya RF;Ellerby LM Ye X(et al.) ] / Nat Med
24 C-terminal fragment of amyloid precursor protein inhibits calcium uptake into rat brain microsomes by Mg2+-Ca2+ ATPase /
[ Kim HS;CH Park;YH Suh ] / Neuroreport
25 C-terminal fragment of Alzheimer's amyloid precursor protein inhibits sodium/calcium exchanger activity in SK-N-SK cell /
[ Kim HS;Lee JH;Suh YH ] / Neuroreport
26 아밀로이드 C단 단백질 투여에 의한 생쥐의 인지 기능과 대뇌피질 및 해마의 아세틸콜린의 변화에 대한 연구 /
[ 최세훈 ] / 서울대 대학원 학위논문(석사)
27 아밀로이드 C단 단백질에 의한 신경교세포의 활성과 염증반응에 관한 신경독성연구 /
[ 라종철 ] / 서울대 대학원 학위논문(석사)
28 Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity /
[ Kim HS;Park CH;Cha SH;Lee JH;Lee S;Kim Y;Rah JC;Jeong SJ;Suh YH ] / FASEB J
29 Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity /
[ Seo J;Kim S;Kim H;Park CH;Jeong S;Lee J;Choi SH;Chang K;Rah J;Koo J;Kim E;Suh ] / Biol Psychiatry
30 Roles of A beta and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease /
[ Suh YH;Kim HS;Lee JP;Park CH;Jeong SJ;Kim SS;Rah JC;Seo JH;Kim S ] / J. Neural Transm
31 痴매의 병리에 대한 동서의학적 고찰 /
[ 강형원(외) ] / 동의병리학회지
32 The structure of the presenilin 1 (SI82) gene and identification of six novel mutation in early onset AD families /
[ Alzheimer's disease collaborative group ] / Nat Genet
33 조구등과 홍삼의 성분에 관한 연구 /
[ 김종문 ] / 서울대 대학원 학위논문(박사)
34 釣鉤藤이 <TEX>${\beta}$</TEX>APP 과발현 인간세경아세포암에서의 항치매효과에 대한 연구 /
[ 김상호;강형원;류영수 ] / 동의생리병리학회지
35 조구등 성분의 항경련효과Ⅱ. 메탄올추출물 및 에틸 아세테이트 분획의 뇌 신경전달 관련물질에 미치는 효과 /
[ 김동영;최종원;박종철;이정규 ] / 생약학회지
36 Related Articles, Links : Cardiovascular effects in the rat of dihydrocorynantheine isolated from Uncaria callophylla /
[ Chang P;Koh YK;Geh SL;Soepadmo E;Goh SH;Wong AK. ] / J Ethnopharmacol.
37 Geissoschizine methyl ether, an indole alkaloid extracted from Uncariae Ramulus et Uncus, is a potent vasorelaxant of isolated rat aorta /
[ Mitsutoshi Yuzurihara;Yasushi Ikarashi;Kazuhiro Goto;Iwao Sakakibara;Terumasa Hayakawa;Hiroshi Sasaki. ] / European Journal of Pharmacology
38 조구등이 산소자유기에 의하여 손상된 배양척수감각신경절세포에 미치는 영향에 관한 연구 /
[ 강형원 ] /
39 조구등(釣鉤藤) 성분의 항경련 효과 Ⅰ;에틸아세테이트 분획의 항경련 효과 /
[ 김동영 ] / 생약학회지
40 조구등의 phospholipase C<TEX>${\gamma}$</TEX>1 저해 성분과 그 항암 효과 /
[ 이지숙 ] / 서울대 대학원 학위논문(박사)
41 치매에 대한 문헌적 고찰 /
[ 정인철;이상용 ] / 동의신경정신과학회지
42 치매에 관한 최근의 연구 동향 /
[ 나창수(외) ] / 대한한방내과학회지
43 Vascular Dementia에 관한 한의학적 임상연구 /
[ 현경철;김종우;황의완 ] / 동의신경정신과학회지
44 녹차로부터 분리된 Epicatechin 3-O-Gallate의 항산화작용 기전에 관한 연구 /
[ 백봉숙(외) ] / 釜山大學校 藥學硏究誌
45 釣鉤藤에 관한 文獻的 硏究 /
[ 李盛雨;盧昇鉉 ] / 大韓韓醫學會誌 第8卷第1號 附錄 本草分科學會誌