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Effect of Kamichungbieum on Allergic Reaction  

Kim Kwang Sik (Department of Pharmacy, Woosuk University)
Lee Dong Hee (Department of Pharmacy, Woosuk University)
Kwon Young An (Department of Science and Engeeniring, Woosuk University)
choi Suh Young (Hana East-West Medical Center)
Eun Jae Soon (Department of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.3, 2004 , pp. 857-862 More about this Journal
Abstract
The purpose of this research was to investigate the effects of supercritical fluid extract of Kamichungbieum (SFE) on allergic reaction. SFE (500 mg/kg) inhibited the systemic anaphylaxis induced by compound 48/80 or platelet activating factor and inhibited the passive cutaneous anaphylaxis (PCA) induced by anti-dinitrophenyl (DNP)-lgE and DNP-human serum albumin (HSA) in vivo. Also, SFE inhibited the SRSC-induced delayed type hypersensitivity and inhibited the hind paw edema induced by histamine. In addition, SFE inhibited the permeability of evans blue induced by acetic acid and inhibited the writhing syndrome induced by acetic acid. These results indicate that SFE may be useful for the prevention and treatment of allergy related disease.
Keywords
Kamichungbieum(加味淸鼻飮); supercritical fluid extract; compound 48/80; PCA; DNP-lgE; writhing syndrome;
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