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The Effects of Hibiscus Syriacus Extract on the Alzheimer's Disease Mice Model Induced by $\betaA$  

Lee Sang Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Jung In Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.3, 2004 , pp. 797-807 More about this Journal
Abstract
This research investigates the effect of the Hibiscus syriacus(HSS) on Alzheimer's disease. The effects of the HSS extract on the behavior in the Morris water maze experiment; the expression of IL-1β, TNF-α, IL-1β mRNA, TNF-α mRNA, CD68/GFAP and RDS; the the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with M were investigated. The HSS extract group showed a significant inhibitory effect on the memory deficit on the mice with Alzheimer's disease induced by βA in the Morris water maze experiment. The HSS extract group suppressed the over-expression of IL-1β, TNF-α, IL-1β and TNF-α mRNA, CD68/GFAP, RDS in the mice with Alzheimer's disease induced by βA. The HSS extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. This study suggest that HSS may be effective for the prevention and treatment of Alzheimer's disease
Keywords
Hibiscus syriacus(HSS); Dementia; Alzheimer's disease; βA; cytokine;
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Times Cited By KSCI : 1  (Citation Analysis)
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