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Inhibitory Effect of Water Extract of Adenophorae Radix on the Melanogenesis  

Kang Hyun Sung (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University)
Lim Nan Young (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Mun Yeun Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lim Hong Jin (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University)
Park Min Chul (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University)
Lim Kyu Sang (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University)
Kim Nam Kwen (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University)
Woo Won Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.2, 2004 , pp. 440-445 More about this Journal
Abstract
The aim of this study was to investigate the effect of Adenophorae Radix (AR) on melanogenesis of B16F10 mouse melanoma cells. The cells were treated for 5 days with AR at several concentrations. Treatment with AR suppressed melanin contents as a dose dependent manner without cytotoxicity and morphological change. And the extract of AR also inhibited tyrosinase activity, a key enzyme forming melanin, in a dose-dependent manner, Treatment of the cells with Adenophorae Radix also suppressed the increase of α-MSH (10 nM)-induced melanin contents and tyrosinase activity. These results suggest that AR inhibits melanogenesis and abrogates α-MSH-induced melanogenesis in B16 melanoma cells.
Keywords
Adenophorae Radix; melanogenesis; tyrosinase; melanin;
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