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Immunomodulatory Effect of Methanol Extracts of Korean Oldenlandiae Herba and Radix  

Lee Eun Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Rhee Yun Hee (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Baek Nam In (School of Biotechnology and Plant Metabolism Research Center, Kyunghee University)
Ahn Kyoo Seok (College of Oriental Medicine, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.2, 2004 , pp. 408-412 More about this Journal
Abstract
For the evaluation of immunomodulatory effect of Korean Oldenlandiae Herb (OH) and Radix (OR), our experiment was performed with methanol extracts of Korean Oldenlandiae Herba and Radix. After administration of methanol extracts of Korean OH and OR for 7 days, Balb/C mice were immunized with sheep red blood cells. Four days later, splenic leukocytes were isolated and immunological experiments were performed. Rosette forming cells and plaque forming cells were significantly increased in Korean OH and OR treated mice compared with PBS treated control. Korean OH and OR also enhanced T and B lymphocytes, macrophage and natural killer cells by flowcytometric analysis. LPS-induced TNF-α and IL-6 levels were increased by OH and OR compared with untreated control. These results suggest that Korean OH and OR have immunomodulatory activity through regulation of cell-mediated immune and humoral immune response.
Keywords
Korean Oldenlandia diffusa; Herba; Radix; immunology; cytokine;
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