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Antidiabetic Effects of Herbal Medicine on db/db Mice  

Chang Mun Seog (Department of Oriental Medicine, Kyunghee University)
Jin Hyun Sun (Department of Oriental Medicine, Kyunghee University)
Jung Kye Jin (Department of Oriental Medicine, Kyunghee University)
Park Sun Min (Food and Nutrition, Hoseo University)
Choi Soo Bong (School of Medicine. Konkuk University)
Ko Byoung Seob (Korea Institute of Oriental Medicine)
Park Seong Kyu (Department of Oriental Medicine, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.1, 2004 , pp. 58-62 More about this Journal
Abstract
The effects of herbal medicine on type 2 diabetic animal model were investigated. Herbal medicine were composed with the addition of Coicis Semen into Okchun-san (OCS). Commelinae Herba into Gangsim-tang (GST). Scrophulariae Radix into Hyunsamsunki-san (HSK). and Erythrinae Cortex into Yukmijihuang-hwan (YMH). We evaluated anti-hyperglycemic and body weight reduction activity in diabetic db/db mice. The experimental animals were divided into six groups. as control group and five sample groups. Each 200mg/kg/day of OCS, GST, HSK and YMH was administered with orally for 14days long. 5mg/kg/day of acarbose was administered with orally for 14days long. On day 14, OCS-treated db/db mice had significantly lower fasting blood glucose levels compared to control group(296±25.9 versus 593±16.4mg/dl. p<0.001). During the 2 h intraperitoneal glucose tolerance test (IPGTT), all the sample groups were improved compared to control group but insignificantly. After 14days of extract treatment. body weight in control. YMH and acarbose groups were increased. but OCS. GST and HSK groups reduced. However. it did not significantly lower hemoglobin Alc(HbAlc) in blood of db/db mice. These result suggest that OCS could be effective on insulin-independent type 2 diabetes.
Keywords
Type 2 diabetes; db/db mice; Okchun-san (OCS); Anti-hyperglycemia; Body weight change;
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