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Pharmacological Effects of Bioactive Fractions from Brachyglottis monroi  

Kwag Jung Sook (Department of Dental Hygiene, Mokpo Science College)
Na Young Soon (Division of Fashion & Beauty, Konyang University)
Perry Nigel B. (Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Ltd., Department of Chemistry, Otago University)
Kim Hyung Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences, Wonkwang University)
Baek Seung Hwa (Department of Pharmacology, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.1, 2004 , pp. 260-264 More about this Journal
Abstract
The effects of bioactive fractions from Brachyglottis monroi on biological activity were investigated. this bioactive subfraction 6-5 is the most cytotoxic to P388 murine leukaemia cell lines. A comparison of IC/sub 50/ values of these subfraction in cancer cell lines showed that their susceptibility to these subfractions decreased in the following order; Fr. 6-5 > Fr. 6-3 > Fr. 6-6 > Fr. 6-1 > Fr. 6-2 > Fr. 6-4 by the MTT method. Silica gel flash column chromatography concentrated the cytotoxic activity in subfraction 6-5 which eluted with 30% and 40% ethyl acetate : hexane gave a major bioactive (51 mg, P388 IC/sub 50/ 8,286 ng/mL at 7.5 ㎍/disc).
Keywords
Brachyglottis monroi; P388 murine leukaemia cell lines; Cytotoxic activity;
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