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Immunomodulatory activity of phytoprotein isol Acanthopanax senticosus : Regulation of CTL responses and activation of macrop

Lee Seok Won (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Lee Soo Jin (Department of Physiology, College of Oriental Medicine, Sangji University)
Park Jeon Ran (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Kim Ha na (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Ahn Kyoo Seok (Department of oriental pathology, Oriental Medical College, Kyunghee University)
Kim Jung-Hyo (Chosun Nursing College)
Baek Nam-in (School of Biotechnology and Plant Metabolism Research Center, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.1, 2004 , pp. 230-235 More about this Journal

Abstract

We previously reported that the phytoprotein extracted from Acanthopanax senticosus (PA) had anti-carcinogenic anti-metastatic activity via increase of inhibition of gap junctional intercellular communication. In the present study investigated the immunomodulatory mechanism of phytoprotein isolated from the stem bark of Acanthopanax sentic (PA). PA was found to significantly stimulate macrophages producing TNF-α and IL-1β in vitro. It also showed tumori activity indicating that PA had the ability to stimulate macrophage directly. Moreover, PA induced the CDB/sup +/ CTL cy responses to recognize antigen on the B16-BL6 melanoma cells. Treatment of PA with B16-BL6 melanoma cells increased the proliferation of splenocytes compared with untreated control. These results demonstrate that PA immunomodulatory activity suggesting a useful anti-tumor agent applicable to treatment and prevention of cancer.

Keywords

Acanthopanax senticosus; phytoprotein; macrophage; Cytotoxic T lymphocyte; cytokines; TNF-α; IL-1β;

Citations & Related Records

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