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Effects of Gunjung-tang on Allergic Reaction  

Kang Kyung Hwa (Department of Physiology, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University)
Choi Yung Hyun (Department of Anatomy, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University)
Choi Byung Tae (Department of Biochemistry, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University)
Lee Yong Tae (Department of Physiology, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.6, 2003 , pp. 1487-1492 More about this Journal
Abstract
Gunjung-tang(GJT) has been reported at Shanghanlun(傷寒論), which has been used for the treatment of general weakness, digestive organ disease and the treatment of allergic disorders in clinical medicine. However, its effect in experimental models remains unknown. In a rat and mouse model, the role of GJT was examined in mast cell-dependent allergic reactions and secretion of inflammatory cytokines. GJT inhibited anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by Intraperitoneal pretreatment. GJT inhibited both IL-1β and TNF-α secretion on egg albumin induced allergic tissues and compound 48/80 induced thymus. Furthermore, GJT enhanced Band T lymphocytes proliferation. Our findings provide evidence that GJT inhibits the IgE-dependent allergic reactions and inflammatory cytokines secretion, and enhanced immune response.
Keywords
Gunjung-tang(健中湯); allergy; IgE; cytokine; NO;
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  • Reference
1 /
[ 李淵台 ] / 最新免疫學
2 /
[ 金一赫;趙弼衡(譯) ] / 韓方醫藥學
3 /
[ 서울대학교醫科大學(編) ] / 免疫學
4 /
[ 김태규(외) ] / 免疫生物學
5 /
[ 盧寬澤 ] / 耳鼻咽喉科學
6 /
[ 張介賓 ] / 景岳全書
7 /
[ 蔡仁植 ] / 傷寒論譯詮
8 /
[ 辛民敎 ] / 原色臨床本草學
9 小建中湯加 龍骨.牡蠣가 흰쥐의 實驗的 胃潰瘍에 미치는 影響 /
[ 金兌仲 ] / 석사학위논문
10 The antioxidant effect, cell viability and the effect to the gene expression using cDNA microarray assay of Shogunjung-tang ga yongglo.morea /
[ 金兌仲 ] / 박사학위논문
11 小建中湯과 六辰丹이 白鼠의 成長發育에 미치는 影響 /
[ 尹漢龍 ] / 석사학위논문
12 黃耆建中湯合理中湯이 抗遺瘍 및 胃腸管 機能에 미치는 效果에 對한 實驗的 硏究 /
[ 成銀美 ] / 석사학위논문
13 黃　建中湯 및 加味黃　建中湯이 흰쥐의 運動 疲勞恢復에 미치는 影響 /
[ 趙仁珠 ] / 석사학위논문
14 Role of TGF-beta1 on the IgE-dependent anaphylaxis reaction /
[ Kim, H.M.;Lee, Y.M. ] / J. Immunol.
15 Native heparin from rat peritoneal mast cells /
[ Yurt, R.W.;Leid, R.W.;Austen, K.F. ] / J. Biol. Chem.
16 A method for fluorometric assay of histamine in tissues /
[ Shore, P.A.;Burkhalter. A.;Cohn, V.H. ] / J. Pharmacol. Exp. Ther.
17 Mediators of immediate hypersensitivity /
[ Ho, P.C.;Lewis, R.A.;Austen, K.F.;Orange, R.P.;Gupta, S.;Good, R.A.(Eds.) ] / Cellular, Molecular, and Clinical Aspects of Allergic Disorders
18 Antiallergy drugs from Oriental medicines /
[ Kim, H.M. ] / Int. J. Orient. Med.
19 /
[ 白萬基 ] / 最新耳鼻咽喉科學
20 A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous allergy in guinea pigs and rats /
[ Katayama, S.;Shionoya, H.;Ohtake, S. ] / Microbiol. Immunol.
21 Ocular anaphylaxis induced in the rat by topical application of compound 48/80. Dose response and time course study /
[ Allansmith, M.R.;Baird, R.S.;Ross, R.N.;Barney, N.P.;Bloch, K.J. ] / Acta Ophthalmol.