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Effects of Kamichihyo-san on Anti-CD40 and Recombinant Interleukin-4 Induced Cytokine Production and Immunoglobulin E in Highly Purified Mouse B Cells  

Ham Chul in (Department of Internal Medicine, College of Oriental Medicine, Taejon University)
Park Yang chun (Department of Internal Medicine, College of Oriental Medicine, Taejon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.6, 2003 , pp. 1479-1486 More about this Journal
Abstract
In order to evaluate the antiallergic effects of Kamiohihyosan(KCHS), studies were done. We measured the cytotoxic activity for lung fibroblast cell, cytokines transcript expression, production of IL-4, IL-10, IFN-γ, proliferation of B cell in anti-CD40mAb plus rIL-4 stimulated murine splenic B cells. The results were obtained as follows: KCHS was not showed cytotoxicity in the fibroblast lung cell, KCHS increased the gene synthesis of INF-γ, TNF-α, IL1-β, IL-6, IL-10(m-RNA), KCHS decreased the gene synthesis of IL-4, IL-5, TGF-β(m-RNA), KCHS decreased the appearance of IL-4, IgE significantly, KCHS increased the appearance of IL-10, IFN-γ significantly, KCHS decreased the proliferation of B cell significantly, The facts above prove that KCHS is effective against the allergy. Thus, I think that we should study on this continuously.
Keywords
Kamichihyosan(加味治哮散); IL-4; IL-10; IFN-γ; antiallergic effects;
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