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The Combined Effect of Moschus and Anti-tumor drug Mitomycin C  

Eun Jae Soon (Department of Pharmacy, Woosuk University)
Kim Dae Keun (Department of Pharmacy, Woosuk University)
Song Jung Mo (College of Oriental Medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.6, 2003 , pp. 1404-1408 More about this Journal
Abstract
The combined effects of water-soluble fraction of Moschus (ME) and anti-tumor drug mitomycin C on the proliferation of human tumor cell-lines were estimated by MTT colorimetric assay. ME inhibited the proliferation of Hep G2, A540, HeLa, KHOS-NP and Balb/c 3T3 cells. Also, ME increased the cytotoxicity of mitomycin C on Hep G2, A549 and HeLa cells. In addition, ME enhanced the cell viability of murine splenocytes and human lymphocytes at the concentration of 100㎍/㎖. These results indicate that ME inhibits the proliferation of human tumor cells and increases the cytotoxicity of mitomycin C without cytoxicity on immune cells.
Keywords
Moschus; mitomycin C; human tumor cell-lines; splenocytes;
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