Browse > Article

Anti-osteoporotic effect of Salvia miltiorrhiza extracts  

Chae Han Jung (Department of Oriental Medical Informatics. Professional Graduate School of Oriental Medicine, Wonkwang University)
Keum Kyung Soo (Department of Oriental Medical Informatics. Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1325-1329 More about this Journal
Abstract
The preventive effect of Salvia miltiorrhiza extracts (SMEs) on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. We measured body weight and bone histomorphometry in sham, OVX or SMEs-administered OVX rats. From light microscopic analyses, a porous or erosive appearances were observed on the surface of trabecular bone of tibia in OVX rats, whereas those of the same bone in sham rats and in SMEs-administered rats were composed of fine particles. The trabecular bone area and trabecular thickness in OVX rats decreased by 50% from those in sham rats, these decreases were completely inhibited by administration of SMEs for 7 weeks. In this study, the mechanical strength in femur neck was significantly enhanced by the treatment of SMEs for 7 weeks. In OVX rats, free T3 was normal in all cases, whereas free T4 was significantly increased. Although there was no difference between OVX and SMEs-administered rats in T3 level, we have found significant difference between them in T4 level. These results strongly suggest that SMEs are effective in preventing the development of bone loss induced by OVX in rats.
Keywords
Ovariectomy (OVX); Salvia miltiorrhiza extracts (SMEs); osteoclast; osteoblast; Serum biochemistry; Bone histomorphometry;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Osteoporosis: assessment of bone loss and remodeling /
[ McGowan, J.A. ] / Aging (Milano)
2 Sequentialand precise in vivo measurement of bone mineral density in rats using dual-energy x-ray absorptiometry /
[ Ammann P.;Rizzoli R.;Slosman D.;Bonjur J.P. ] / J. Bone. Miner. Res.   ScienceOn
3 Premenopausal and postmenopausal changes in bone mineral density of the proximal femurmeasured by dual-energy x-ray absorptionmetry /
[ Ravn, P.;Hetland, M.L.;Overgaard, K.;Christiansen, C. ] / J. Bone Miner Res.   ScienceOn
4 Effects of ovariectomy on biochemical and bone variables in the rat /
[ Morris, H.A.;Porter, S.J.;Durbridge, T.C.;Moore, R.J.;Need, A.G.;Nordin, B.E.C. ] / Bone Miner.   ScienceOn
5 The effect of ovariectomy on periosteal bone formation and bone resorption in adult rats /
[ Hietala, E.L. ] / Bone Miner.   ScienceOn
6 The aged rat model of ovarian hormone deficiency bone loss /
[ Kalu, D.N.;Liu, C.C.;Hardin, R.R.;Hollis, B.W. ] / Endocrinology   ScienceOn
7 Effect of estrogen replacement on liver function in ovariectomised rats /
[ Nagae, Y.;Miayamoto, M.;Miyamoto, H. ] / J. Tox. Sci.
8 Identification of estrogen receptor mRNA and the estrogen modulation of parathyroid hormone-stimulated cyclic AMP accumulation in opossum kidney cells /
[ Stock, J.L.;Coderre, J.A.;Burke, E.M.;Danner, D.B.;Chipman, S.D.;Shapiro, R.J. ] / J. Cell Physiol.
9 Involutional osteoporosis /
[ Riggs, B.L.;Melton, L.J. 3d. ] / N. Engl. J. Med.   ScienceOn
10 Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium /
[ Ettinger, B.;Genant, H.K.;Cann, C.E. ] / Ann. Intern. Med.
11 The ovariectomized rat model of postmeno- pausal bone loss /
[ Kalu, D.N. ] / Bone Miner.   ScienceOn
12 Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone /
[ Chen, X.G.;Li, Y.;Yan, CH.;Li, LN.;Han, R. ] / J Asian Nat Prod Res.   ScienceOn
13 Neural involvement in post-traumatic osteopenia: an experimental study in the rat /
[ Madsen, J.E.;Aune, A.K.;Falch, J.A.;Hukkanen, M.;Konttinen, Y.T.;Santavirta, S.;Nordsletten, L. ] / Bone.   ScienceOn
14 Effects of thyroid hormones on bone and mineral metabolism /
[ Mosekilde, L.;Eriksen, E.F.;Charles, P. ] / Endocrinol. Metab. Clin. North Am.
15 Bone changes in hyper- thyroidism: interrelationships between bone morphometry, thyroid function and calcium-phosphorus metabolism /
[ Mosekilde, L.;Melsen, F.;Bagger, J.P.;Myhre-Jensen, O.;Schwartz Sorensen, N. ] / Acta. Endocrinol. (Copenh)
16 Anti-fibrotic effects of a hot-water extract from Salvia miltiorrhiza roots on liver fibrosis induced by biliary obstruction in rats /
[ Nan, J.X.;Park, E.J.;Kang, H.C.;Park, P.H.;Kim, J.Y.;Sohn, D.H. ] / J Pharm Pharmacol.   ScienceOn
17 Experimental study of hirudo and Salvia miltiorrhiza on smooth muscle cell hyperplasia after balloon angioplasty /
[ Zhang, T.;Du, L.;Cui, P. ] / Zhongguo Zhong Xi Yi Jie He Za Zhi.
18 Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats /
[ Wronski, T.J.;Yen, C.F.;Qi, H.;Dann, L.M. ] / Endocrinology   ScienceOn
19 Histo-anatomical characteristics of the proximal femur in mature rats. Impact of ovariectomy /
[ Bagi, C.M.;DeLeon, E.;Rizzoli, R.;Ammann, P.;Miller, S.C. ] / Anat. Rec.   ScienceOn
20 Dual energy x-ray absorptiometry of the rat-accuracy, precision, and measurement of bone loss /
[ Griffin, M.G.;Kimble, R.;Hopfer, W.;Pacifici, R. ] / J. Bone Miner. Res.   ScienceOn