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Antimalarial activity of marine alga aganist P. falciparum in vitro  

Kim Hye Sook (Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Okayama)
Wataya Yusuke (Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Okayama)
Takaya Yoshiaki (Faculty of Pharmacy, Meijo University, Yagotoyama, Tempaku-ku, Nagoya, Japan)
Ahnn Joo Hong (Department of Life Science, Kwangju Institute of Science and Technology, Kwangju)
Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Shin Ho Joon (Department of Microbiology, Ajou University School of Medicine)
Shin Chang Ho (Department of Parasitology, College of Medicine, Wonkwang University)
Kim Yong Man (Department of Parasitology, College of Medicine, Wonkwang University)
Park Hyun (Department of Parasitology, College of Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1321-1324 More about this Journal
Abstract
To produce anti-malarial drugs, natural products were extracted from 18 species of marine algae by various mechanical methods. Twelve species of marine algae were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC/sub 50/ values less than 100 ㎍/㎖. The methanol extract of Neoholmeria japonica had the strongest antiplasmodial activity with EC/sub 50/ value of 62 ㎍/㎖.
Keywords
Plasmodium falciparum; Neoholmeria japonica; antiplasmodial activity;
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