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Effect of Fructus Rubi on the isolated rat aorta  

Sun Sung Gyu (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Oh Kwang Soo (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Kim Nam Soon (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
So Eung Hyang (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Hang Jong Hyun (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.5, 2003 , pp. 1299-1304 More about this Journal
Abstract
This study is to determine the effect of Fructus Rubi to the phenylehrine (PE) induced contraction of isolated rat aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. Contractions evoked by PE 0.1 μM and KCI 65.4 mM were decreased significantly by Fructus Rubi. L-NNA, ODQ, indomethacin and atropine significantly altered the effect of Fructus Rubi, but propranolol did not change the relaxation of Fructus Rubi. These results indicate that Fructus Rubi can relax EP and KCI induced contraction of isolated rat aorta and that this decreasing contraction related to epithelium, nitric oxide, and parasympathetics.
Keywords
Contraction; relaxation; aorta; phenylehrine; Fructus Rubi;
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  • Reference
1 Endothelium-derived nitric oxide: action and properties /
[ Ignarro, L.J. ] / FASEB J.
2 /
[ 신민교 ] / 원색 임상본초학
3 /
[ 전국한의과대학 본초학교수(공저) ] / 본초학
4 /
[ Rang, H.P.;Dale, M.M.;Ritter, J.M. ] / Pharmcology
5 Endothelium- dependent relaxation resistant to NG-nitro-L-arginine in rat aorta /
[ Hadake, K.;Wakabayashi, I.;Hishda, S. ] / Eur. J. Pharm.
6 A major role for prostacyclin in nitric oxide-induced occular vasorelaxation in the piglet /
[ Hardy, P.;Abran, D.;Hou, X.;Lahaie, I.;Peri, K.G.;Asselin, P.;Varma, D.R. Chemtob, S. ] / Cicr Res.
7 Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of R. suavissimus, and identification of the source plant of the Chinese folk medicine /
[ Chou, W.H.;Oinaka, T.;Kanamaru, F.;Mizutani, K.;Chen, F.H.;Tanaka, O. ] / Chem Pharm Bull
8 /
[ 허준 ] / 동의보감
9 /
[ 서부일(외) ] / 국역본초비요
10 Continuity and changes of breeds of fupenzi /
[ Wang, H. ] / Zhongguo Zhong Yao Za Zhi
11 Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties /
[ Mullen, W.;McGinn, J.;Lean, M.E.;MacLean, M.R.;Gardner, P.;Duthie, G.G.;Yokota, T.;Crozier, A. ] / J Agric Food Chem   ScienceOn
12 Effects of the fruit of Rubus chingii Hu on hypothalamus-pituitary-sex gland axis in rats /
[ Chen, K.;Fang, J.;Kuang, X.;Mo, Q. ] / Zongguo Zhong Yao Za Zhi
13 Hypoglycaemic effect of Rubus fructicosis L. and Globularia alypum L. in normal and streptozotocin-induced diabetic rats /
[ Jouad, H.;Maghrani, M.;Eddouks, M. ] / J Ethnopharmacol   ScienceOn
14 Cytotoxic, hypoglycemic activity and phytochemical analysis of Rubus imperialis (Rosaceae) /
[ Kanegusuku, M.;Benassi, J.C.;Pedrosa, R.C.;Yunes, R.A.;Filho, V.C.;Maia, A.A.;de Souza, M.M.;Delle Monache F.;Niero, R. ] / Z Naturforsch [C]
15 Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies /
[ Hsieh, T.C.;Lu, X.;Guo, J.;Xiong, W.;Kunicki, J.;Darzynkiewicz, Z.;Wu, J.M. ] / Int J Oncol
16 Action of Rubus coreanus extract on systemic and local anaphylaxis /
[ Shin, T.Y.;Kim, S.H.;Lee, E.S.;Eom, D.O.;Kim, H.M. ] / Phytother Res.   ScienceOn
17 Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases /
[ Murakami, C.;Ishijima, K.;Hirota, M.;Sakaguchi, K.;Yoshida, H.;Mizushina, Y. ] / Biochim Biophys Acta.
18 Antinociceptive action of extracts and fractions from Rubus imperialis (Rosaceae) /
[ Niero, R.;Kanegusuku, M.;Souza, M.M.;Yunes, R.A.;Cechinel-Filho, V. ] / Therapie
19 Antibacterial effect of a magnetic field on Serratia marcescens and related virulence to Hordeum vulgare and Rubus fruticosus callus cells /
[ Piatti, E.;Cristina Albertini M.;Baffone, W.;Fraternale, D.;Citterio, B.;Piera Piacentini M.;Dacha, M.;Vetrano, F.;Accorsi, A. ] / Comp Biochem Physiol B Biochem Mol Biol.   ScienceOn
20 Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. against hepatitis B virus /
[ Kim, T.G.;Kang, S.Y.;Jung, K.K.;Kang, J.H.;Lee, E.;Han, H.M.;Kim, S.H. ] / Phytother Res   ScienceOn
21 Relaxant activity of raspberry ( Rubus idaeus) leaf extract in guinea-pig ileum in vitro /
[ Rojas-Vera, J.;Patel, A.V.;Dacke, C.G. ] / Phytother Res   ScienceOn
22 An aqueous extract of Rubus chingii fruits protects primary rat hepatocytes against tert-butyl hydroperoxide induced oxidative stress /
[ Yau, M.H.;Che, C.T.;Liang, S.M.;Kong, Y.C.;Fong, W.P. ] / Life Sci   ScienceOn
23 Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant /
[ Nakatani, K.;Atsumi, M.;Arakawa, T.;Oosawa, K.;Shimura, S.;Nakahata, N.;Ohizumi, Y. ] / Biol Pharm Bull   ScienceOn
24 Pflugers Arch, ges. /
[] / Physiol.
25 /
[ Snedecor, G.H.;Cochran, W.G. ] / Statistical Methods